A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro.

Animals Cell Line Environmental Pollutants / pharmacology Humans Polychlorinated Biphenyls / chemistry Rats Receptors, Aryl Hydrocarbon / agonists Transcriptional Activation / drug effects
Antagonistic activity Aryl hydrocarbon receptor Generalized concentration addition model Human relevant mixture Persistent organic pollutants

Journal

Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 10 07 2019
revised: 16 08 2019
accepted: 21 08 2019
pubmed: 4 9 2019
medline: 24 12 2019
entrez: 4 9 2019
Statut: ppublish

Résumé

While humans are exposed to mixtures of persistent organic pollutants (POPs), their risk assessment is usually based on a chemical-by-chemical approach. To assess the health effects associated with mixed exposures, knowledge on mixture toxicity is required. Several POPs are potential ligands of the Aryl hydrocarbon receptor (AhR), which involves in xenobiotic metabolism and controls many biological pathways. This study assesses AhR agonistic and antagonistic activities of 29 POPs individually and in mixtures by using Chemical-Activated LUciferase gene eXpression bioassays with 3 transgenic cell lines (rat hepatoma DR-H4IIE, human hepatoma DR-Hep G2 and human mammary gland carcinoma DR-T47-D). Among the 29 POPs, which were selected based on their abundance in Scandinavian human blood, only 4 exerted AhR agonistic activities, while 16 were AhR antagonists in DR-H4IIE, 5 in DR-Hep G2 and 7 in DR-T47-D when tested individually. The total POP mixture revealed to be AhR antagonistic. It antagonized EC

Identifiants

DOI: 10.1016/j.envpol.2019.113098 PMID: 31479813
pubmed: 31479813
pii: S0269-7491(19)33697-8
doi: 10.1016/j.envpol.2019.113098
pii:
doi:

Substances chimiques

Environmental Pollutants 0
Receptors, Aryl Hydrocarbon 0
2,3',4,4',5-pentachlorobiphenyl 2B2AQE8U50
2,2',3',4,4',5-hexachlorobiphenyl 7Y6JIG1867
Polychlorinated Biphenyls DFC2HB4I0K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113098

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

T Q Doan (TQ)

Laboratory of Food Analysis, FARAH-Veterinary Public Health, University of Liège, Liège, 4000, Belgium.

H F Berntsen (HF)

Department of Production Animal Clinical Sciences, Section of Experimental Biomedicine, NMBU - Faculty of Veterinary Medicine, Oslo, N-0033, Norway; Department of Administration, Lab Animal Unit, National Institute of Occupational Health, P.O. Box 8149 Dep, Oslo, N-0033, Norway.

S Verhaegen (S)

Department of Production Animal Clinical Sciences, Section of Experimental Biomedicine, NMBU - Faculty of Veterinary Medicine, Oslo, N-0033, Norway.

E Ropstad (E)

Department of Production Animal Clinical Sciences, Section of Experimental Biomedicine, NMBU - Faculty of Veterinary Medicine, Oslo, N-0033, Norway.

L Connolly (L)

Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Northern Ireland, BT7 1NN, UK.

A Igout (A)

Department of Biomedical and Preclinical Sciences, Faculty of Medicine, University of Liège, Liège, 4000, Belgium.

M Muller (M)

GIGA-R, Laboratory for Organogenesis and Regeneration, University of Liège, Liège, 4000, Belgium.

M L Scippo (ML)

Laboratory of Food Analysis, FARAH-Veterinary Public Health, University of Liège, Liège, 4000, Belgium. Electronic address: mlscippo@uliege.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A mixture of persistent organic pollutants...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › A mixture of persistent organic pollutants...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › A mixture of persistent organic pollutants...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A mixture of persistent organic pollutants...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Polychlorobiphényles › A mixture of persistent organic pollutants...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › A mixture of persistent organic pollutants...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs à hydrocarbure aromatique › A mixture of persistent organic pollutants...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › A mixture of persistent organic pollutants...