Exploring Shared Susceptibility between Two Neural Crest Cells Originating Conditions: Neuroblastoma and Congenital Heart Disease.

Genetic Predisposition to Disease Heart Defects, Congenital / genetics Humans Linkage Disequilibrium Neural Crest / metabolism Neuroblastoma / genetics Polymorphism, Single Nucleotide Quantitative Trait Loci
congenital heart disease genome wide association studies neuroblastoma

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
30 08 2019
Historique:
received: 07 05 2019
revised: 12 08 2019
accepted: 26 08 2019
entrez: 5 9 2019
pubmed: 5 9 2019
medline: 12 2 2020
Statut: epublish

Résumé

In the past years, genome wide association studies (GWAS) have provided evidence that inter-individual susceptibility to diverse pathological conditions can reveal a common genetic architecture. Through the analysis of congenital heart disease (CHD) and neuroblastoma (NB) GWAS data, we aimed to dissect the genetic susceptibility shared between these conditions, which are known to arise from neural crest cell (NCC) migration or development abnormalities, via identification and functional characterization of common regions of association. Two loci (2q35 and 3q25.32) harbor single nucleotide polymorphisms (SNPs) that are associated at a

Identifiants

DOI: 10.3390/genes10090663 PMID: 31480262 PMC: PMC6771154
pubmed: 31480262
pii: genes10090663
doi: 10.3390/genes10090663
pmc: PMC6771154
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R35 CA220500
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA124709
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204974
Pays : United States
Organisme : British Heart Foundation
ID : RG/15/12/31616
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/13/2/30154
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA180692
Pays : United States

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Auteurs

Alessandro Testori (A)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.

Vito A Lasorsa (VA)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
ORCID: 0000-0002-9552-7192

Flora Cimmino (F)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.

Sueva Cantalupo (S)

IRCCS SDN, Istituto di Ricerca Diagnostica e Nucleare, 80143 Naples, Italy.

Antonella Cardinale (A)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.

Marianna Avitabile (M)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
ORCID: 0000-0002-5352-6503

Giuseppe Limongelli (G)

Division of Cardiology, Università degli Studi della Campania "Luigi Vanvitelli" - AO dei Colli, Presidio Monaldi, 80121 Naples, Italy.

Maria Giovanna Russo (MG)

Division of Cardiology, Università degli Studi della Campania "Luigi Vanvitelli" - AO dei Colli, Presidio Monaldi, 80121 Naples, Italy.

Sharon Diskin (S)

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

John Maris (J)

Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Marcella Devoto (M)

Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Division of Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Department of Translational and Precision Medicine, University of Rome "La Sapienza", 00185 Rome, Italy.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Bernard Keavney (B)

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.
Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M20 4BX, UK.

Heather J Cordell (HJ)

Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.

Achille Iolascon (A)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
ORCID: 0000-0002-9558-0356

Mario Capasso (M)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, 80131 Naples, Italy. mario.capasso@unina.it.
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy. mario.capasso@unina.it.
IRCCS SDN, Istituto di Ricerca Diagnostica e Nucleare, 80143 Naples, Italy. mario.capasso@unina.it.
ORCID: 0000-0003-3306-1259

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Phénomènes génétiques › Liaison génétique › Déséquilibre de liaison › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Structures de l'embryon › Crête neurale › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Exploring Shared Susceptibility between Two...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Exploring Shared Susceptibility between Two...