Insulin Receptor Isoform A Modulates Metabolic Reprogramming of Breast Cancer Cells in Response to IGF2 and Insulin Stimulation.

Antimetabolites / pharmacology Breast Neoplasms / metabolism Cell Movement / drug effects Cell Proliferation / drug effects Deoxyglucose / pharmacology Female Glycolysis Humans Insulin / metabolism Insulin-Like Growth Factor II / metabolism MCF-7 Cells Metformin / pharmacology Mitochondria / drug effects Protein Isoforms / genetics Receptor, IGF Type 1 / genetics
IGF1R IGF2 aerobic glycolysis breast cancer insulin receptor isoform A metabolic flexibility metabolic reprogramming

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
01 09 2019
Historique:
received: 05 08 2019
revised: 27 08 2019
accepted: 29 08 2019
entrez: 5 9 2019
pubmed: 5 9 2019
medline: 15 5 2020
Statut: epublish

Résumé

Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis. The IR has a predominant metabolic role in physiology, but the potential role of IR-A in cancer metabolic reprogramming is unknown. We aimed to characterize the metabolic impact of IR-A and its ligand insulin like growth factor 2 (IGF2) in human breast cancer (BC) cells. To establish autocrine IGF2 action, we generated human BC cells MCF7 overexpressing the human IGF2, while we focused on the metabolic effect of IR-A by stably infecting

Identifiants

DOI: 10.3390/cells8091017 PMID: 31480557 PMC: PMC6770491
pubmed: 31480557
pii: cells8091017
doi: 10.3390/cells8091017
pmc: PMC6770491
pii:
doi:

Substances chimiques

Antimetabolites 0
IGF1R protein, human 0
IGF2 protein, human 0
Insulin 0
Protein Isoforms 0
Insulin-Like Growth Factor II 67763-97-7
Metformin 9100L32L2N
Deoxyglucose 9G2MP84A8W
Receptor, IGF Type 1 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Veronica Vella (V)

Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania 95122, Italy.

Maria Luisa Nicolosi (ML)

Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania 95122, Italy.

Marika Giuliano (M)

Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania 95122, Italy.

Andrea Morrione (A)

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Roberta Malaguarnera (R)

School of Human and Social Sciences, "Kore" University of Enna, Enna 94100, Italy.

Antonino Belfiore (A)

Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania 95122, Italy. antonino.belfiore@unict.it.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Antimétabolites › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-II › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Insulin Receptor Isoform A Modulates Metabolic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs des somatomédines › Récepteur IGF de type 1 › Insulin Receptor Isoform A Modulates Metabolic...