Antivirals and vaccines for Enterovirus A71.
Antivirals
Enterovirus A71
Vaccines
Journal
Journal of biomedical science
ISSN: 1423-0127
Titre abrégé: J Biomed Sci
Pays: England
ID NLM: 9421567
Informations de publication
Date de publication:
03 Sep 2019
03 Sep 2019
Historique:
received:
27
06
2019
accepted:
23
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
25
12
2019
Statut:
epublish
Résumé
Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or severe neurological complications. However, there are still no effective antivirals for treatment of these infections. In this review, we summarize the antiviral compounds developed to date based on various targets of the EV-A71 life cycle. Moreover, development of a vaccine would be the most effective approach to prevent EV-A71 infection. Therefore, we also summarize the development and clinical progress of various candidate EV-A71 vaccines, including inactivated whole virus, recombinant VP1 protein, synthetic peptides, viral-like particles, and live attenuated vaccines.
Identifiants
pubmed: 31481071
doi: 10.1186/s12929-019-0560-7
pii: 10.1186/s12929-019-0560-7
pmc: PMC6720414
doi:
Substances chimiques
Antiviral Agents
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
65Subventions
Organisme : National Science Council
ID : MOST 108-3017-F-182-001
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