Intranasal dexmedetomidine and intravenous ketamine for procedural sedation in a child with alpha-mannosidosis: a magic bullet?
Administration, Intranasal
Anesthetics, Dissociative
/ administration & dosage
Child, Preschool
Dexmedetomidine
/ administration & dosage
Humans
Hypnotics and Sedatives
/ administration & dosage
Infusions, Intravenous
Ketamine
/ administration & dosage
Magnetic Resonance Imaging
Male
Spinal Puncture
alpha-Mannosidosis
/ diagnostic imaging
Alpha-mannosidosis
Dexmedetomidine
Ketamine
Procedural sedation
Journal
Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759
Informations de publication
Date de publication:
03 Sep 2019
03 Sep 2019
Historique:
received:
05
04
2019
accepted:
22
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
27
3
2020
Statut:
epublish
Résumé
Procedural sedation is increasingly needed in pediatrics. Although different drugs or drugs association are available, which is the safest and most efficient has yet to be defined, especially in syndromic children with increased sedation-related risk factors. we report the case of a five-year-old child affected by alpha-mannosidosis who required procedural sedation for an MRI scan and a lumbar puncture. We administered intranasal dexmedetomidine (4 μg/kg) 45 min before intravenous cannulation, followed by one bolus of ketamine (1 mg/kg) for each procedure. The patient maintained spontaneous breathing and no desaturation or any complication occurred. intranasal dexmedetomidine and intravenous ketamine could be a feasible option for MRI and lumbar puncture in children with alpha-mannosidosis needing sedation.
Sections du résumé
BACKGROUND
BACKGROUND
Procedural sedation is increasingly needed in pediatrics. Although different drugs or drugs association are available, which is the safest and most efficient has yet to be defined, especially in syndromic children with increased sedation-related risk factors.
CASE REPORT
METHODS
we report the case of a five-year-old child affected by alpha-mannosidosis who required procedural sedation for an MRI scan and a lumbar puncture. We administered intranasal dexmedetomidine (4 μg/kg) 45 min before intravenous cannulation, followed by one bolus of ketamine (1 mg/kg) for each procedure. The patient maintained spontaneous breathing and no desaturation or any complication occurred.
CONCLUSION
CONCLUSIONS
intranasal dexmedetomidine and intravenous ketamine could be a feasible option for MRI and lumbar puncture in children with alpha-mannosidosis needing sedation.
Identifiants
pubmed: 31481093
doi: 10.1186/s13052-019-0711-1
pii: 10.1186/s13052-019-0711-1
pmc: PMC6720406
doi:
Substances chimiques
Anesthetics, Dissociative
0
Hypnotics and Sedatives
0
Dexmedetomidine
67VB76HONO
Ketamine
690G0D6V8H
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119Références
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