Development of brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease.
Cannabinoid receptor type 2
Colony stimulating factor 1 receptor
Cyclooxygenase-2
Microglia
Microglial activation
Neuroinflammation
P2X(7) receptor
Positron emission tomography
Reactive oxygen species
Translocator protein 18kDa
Journal
Progress in molecular biology and translational science
ISSN: 1878-0814
Titre abrégé: Prog Mol Biol Transl Sci
Pays: Netherlands
ID NLM: 101498165
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
18
4
2020
Statut:
ppublish
Résumé
Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease. PET imaging of neuroinflammation, which is characterized by the activation of glial cells in the central nervous system (CNS), has been traditionally studied using radiotracers targeting the translocator protein 18kDa (TSPO). However, limitations in the properties of PET radiotracers for imaging the TSPO has led to the search for alternative strategies for imaging neuroinflammation. The current review presents the current status of PET radiotracers for imaging the TSPO, and describes alternative biological targets that have gained interest for imaging of microglial activation over recent years. These include cannabinoid receptor type-2, cyclooxygenase-2, the P2X
Identifiants
pubmed: 31481170
pii: S1877-1173(19)30064-X
doi: 10.1016/bs.pmbts.2019.04.005
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Receptors, GABA
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
371-399Informations de copyright
© 2019 Elsevier Inc. All rights reserved.