The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils.
Animals
Bacterial Proteins
/ metabolism
Chemotaxis
Gene Expression Regulation
/ drug effects
Immunoprecipitation
Male
Mice
Mice, Inbred C57BL
Neutrophils
/ drug effects
PTEN Phosphohydrolase
/ genetics
Phosphatidylinositol 3-Kinase
/ metabolism
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
/ genetics
Phosphatidylinositols
/ metabolism
Porins
/ metabolism
Treponema denticola
/ metabolism
PTEN
Treponema denticola
chemotaxis
neutrophils
periodontal disease
phosphoinositide
spirochetes
Journal
Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
07
2019
accepted:
27
08
2019
pubmed:
5
9
2019
medline:
14
1
2020
entrez:
5
9
2019
Statut:
epublish
Résumé
Periodontal disease is a significant health burden, causing tooth loss and poor oral and overall systemic health. Dysbiosis of the oral biofilm and a dysfunctional immune response drive chronic inflammation, causing destruction of soft tissue and alveolar bone supporting the teeth.
Identifiants
pubmed: 31481407
pii: IAI.00553-19
doi: 10.1128/IAI.00553-19
pmc: PMC6803320
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Phosphatidylinositols
0
Porins
0
major outer sheath protein, Treponema
0
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
PTEN Phosphohydrolase
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Inpp5d protein, mouse
EC 3.1.3.86
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
EC 3.1.3.86
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : F32 DE027612
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027073
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE024769
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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