Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells.

Animals Claudins / genetics Female Humans Kidney Tubules / metabolism LLC-PK1 Cells Male Mice Mice, Inbred C57BL Phenotype Rho Guanine Nucleotide Exchange Factors / genetics Swine Trans-Activators / genetics Tumor Necrosis Factor-alpha / genetics Ureteral Obstruction / genetics rhoA GTP-Binding Protein / genetics
Ras homolog gene family, member A (RhoA) claudin epithelial cell epithelial-mesenchymal transition (EMT) guanine nucleotide exchange factor (GEF) p27KIP1 pro-fibrotic epithelial phenotype renal tubules small GTPase tight junction

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
18 10 2019
Historique:
received: 10 11 2018
revised: 21 08 2019
pubmed: 5 9 2019
medline: 23 6 2020
entrez: 5 9 2019
Statut: ppublish

Résumé

The tight junctional pore-forming protein claudin-2 (CLDN-2) mediates paracellular Na

Identifiants

DOI: 10.1074/jbc.RA118.006484 PMID: 31481470 PMC: PMC6802501
pubmed: 31481470
pii: S0021-9258(20)33786-8
doi: 10.1074/jbc.RA118.006484
pmc: PMC6802501
doi:

Substances chimiques

Arhgef2 protein, mouse 0
Claudins 0
Cldn2 protein, mouse 0
Mrtfa protein, mouse 0
Rho Guanine Nucleotide Exchange Factors 0
Trans-Activators 0
Tumor Necrosis Factor-alpha 0
rhoA GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15446-15465

Informations de copyright

© 2019 Dan et al.

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Auteurs

Qinghong Dan (Q)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Yixuan Shi (Y)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Razieh Rabani (R)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Shruthi Venugopal (S)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Jenny Xiao (J)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Shaista Anwer (S)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Mei Ding (M)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Pam Speight (P)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.

Wanling Pan (W)

Departments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.

R Todd Alexander (RT)

Departments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada.
ORCID: 0000-0001-7396-7894

András Kapus (A)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada.
Department of Surgery, University of Toronto, Ontario M5B 1T8, Canada.

Katalin Szászi (K)

Keenan Research Centre for Biomedical Science at St. Michael's Hospital, University of Toronto, Ontario M5B 1T8, Canada katalin.szaszi@unityhealth.to.
Department of Surgery, University of Toronto, Ontario M5B 1T8, Canada.
ORCID: 0000-0002-2490-8422

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de la jonction serrée › Claudines › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Tubules rénaux › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules LLC-PK1 › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Rho guanine nucleotide exchange factors › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies urétérales › Obstruction urétérale › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G RhoA › Claudin-2 suppresses GEF-H1, RHOA, and MRTF,...