Metabolomic analysis of serum may refine 21-gene expression assay risk recurrence stratification.
Breast cancer
Cancer metabolism
Prognostic markers
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
02
2019
accepted:
06
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
5
9
2019
Statut:
epublish
Résumé
Despite recent refinements to the 21-gene g score, allowing a better identification of patients who may derive no benefit from the addition of adjuvant chemotherapy to that of endocrine therapy, patients with early breast cancer still stand to be over-treated in the setting of clinical and/or genomic uncertainty or discordance. Here we describe and demonstrate a potential approach of further refining the OncotypeDX risk score by metabolomic analysis of serum. In a clinical dataset (
Identifiants
pubmed: 31482106
doi: 10.1038/s41523-019-0123-9
pii: 123
pmc: PMC6715716
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Déclaration de conflit d'intérêts
Competing interestsA.D.L. has received honoraria for attending advisory boards and as a speaker at sponsored symposia by Genomic Health. The other authors declare no competing interests.
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