Genome-wide association study of knee pain identifies associations with
Biological Specimen Banks
Case-Control Studies
Cohort Studies
Female
Fibrillar Collagens
/ genetics
Gene Expression Regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Growth Differentiation Factor 5
/ genetics
Humans
Knee Joint
/ pathology
Linkage Disequilibrium
/ genetics
Male
Middle Aged
Pain
/ genetics
Polymorphism, Single Nucleotide
/ genetics
United Kingdom
Genome-wide association studies
Musculoskeletal system
Pain
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
04
2019
accepted:
02
08
2019
entrez:
5
9
2019
pubmed:
5
9
2019
medline:
5
9
2019
Statut:
epublish
Résumé
Knee pain is one of the most common musculoskeletal complaints that brings people to medical attention. Approximately 50% of individuals over the age of 50 report an experience of knee pain within the past 12 months. We sought to identify the genetic variants associated with knee pain in 171,516 subjects from the UK Biobank cohort and seek supporting evidence in cohorts from 23andMe, the Osteoarthritis Initiative, and the Johnston County Osteoarthritis Project. We identified two loci that reached genome-wide significance in the UK Biobank: rs143384, located in
Identifiants
pubmed: 31482140
doi: 10.1038/s42003-019-0568-2
pii: 568
pmc: PMC6713725
doi:
Substances chimiques
COL27A1 protein, human
0
Fibrillar Collagens
0
GDF5 protein, human
0
Growth Differentiation Factor 5
0
Banques de données
figshare
['10.6084/m9.figshare.9611198.v1']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Pagination
321Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : P60 AR049465
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01AR22259
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01AR22262
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01AR22258
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK072488
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01AR22261
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : N01AR22260
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : P60 AR030701
Pays : United States
Investigateurs
Michelle Agee
(M)
Babak Alipanahi
(B)
Robert K Bell
(RK)
Katarzyna Bryc
(K)
Sarah L Elson
(SL)
Pierre Fontanillas
(P)
Nicholas A Furlotte
(NA)
Barry Hicks
(B)
David A Hinds
(DA)
Karen E Huber
(KE)
Ethan M Jewett
(EM)
Yunxuan Jiang
(Y)
Aaron Kleinman
(A)
Keng-Han Lin
(KH)
Nadia K Litterman
(NK)
Jennifer C McCreight
(JC)
Matthew H McIntyre
(MH)
Kimberly F McManus
(KF)
Joanna L Mountain
(JL)
Elizabeth S Noblin
(ES)
Carrie A M Northover
(CAM)
Steven J Pitts
(SJ)
G David Poznik
(GD)
J Fah Sathirapongsasuti
(JF)
Janie F Shelton
(JF)
Suyash Shringarpure
(S)
Chao Tian
(C)
Joyce Y Tung
(JY)
Vladimir Vacic
(V)
Xin Wang
(X)
Catherine H Wilson
(CH)
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
Competing interestsJ.S., A.A. and members of the 23andMe Research Team are employees of 23andMe, Inc., and hold stock or stock options in 23andMe. Other authors declare no competing interests.
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