PTTG1: a Unique Regulator of Stem/Cancer Stem Cells in the Ovary and Ovarian Cancer.
Cancer stem cells
Oncogene
Ovarian cancer
Ovary
PTTG1
Securin
Stem cells
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
5
9
2019
medline:
5
8
2020
entrez:
5
9
2019
Statut:
ppublish
Résumé
Origin of cancer stem cells (CSCs) and mechanisms by which oncogene PTTG1 contributes to tumor progression via CSCs is not known. Ovarian CSCs exhibit characteristics of self-renewal, tumor-initiation, growth, differentiation, drug resistance, and tumor relapse. A common location of putative origin, namely the ovarian surface epithelium, is shared between the normal stem and CSC compartments. Existence of ovarian stem cells and their co-expression with CSC signatures suggests a strong correlation between origin of epithelial cancer and CSCs. We hereby explored a putative oncogene PTTG1 (Securin), reported to be overexpressed in various tumors, including ovarian. We report a previously overlooked role of PTTG1 as a marker of CSCs thereby modulating CSC, germline, and stemness-related genes. We further characterized PTTG1's ability to regulate (cancer) stem cell-associated self-renewal and epithelial-mesenchymal transition pathways. Collectively, the data sheds light on a potential target expressed during ovarian tumorigenesis and metastatically disseminated ascites CSCs in the peritoneal cavity. Present study highlights this unconventional, under-explored role of PTTG1 in regulation of stem and CSC compartments in ovary, ovarian cancer and ascites and highlights it as a potential candidate for developing CSC specific targeted therapeutics.
Identifiants
pubmed: 31482269
doi: 10.1007/s12015-019-09911-5
pii: 10.1007/s12015-019-09911-5
doi:
Substances chimiques
Securin
0
pituitary tumor-transforming protein 1, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
866-879Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL134644
Pays : United States
Organisme : NCI NIH HHS
ID : UO1CA2177798
Pays : United States
Organisme : NIH HHS
ID : T32HL134644
Pays : United States
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