Understanding the links between cardiovascular disease and Parkinson's disease.
Parkinson's disease
cardiovascular
pathogenesis
risk factors
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
06
2019
revised:
16
07
2019
accepted:
01
08
2019
pubmed:
5
9
2019
medline:
18
12
2020
entrez:
5
9
2019
Statut:
ppublish
Résumé
Studies investigating the associations between genetic or environmental factors and Parkinson's disease (PD) have uncovered a number of factors shared with cardiovascular disease, either as risk factors or manifestations of cardiovascular disease itself. Older age, male sex, and possibly type 2 diabetes are examples. On the other hand, coffee consumption and physical activity are each associated with a lower risk of both PD and cardiovascular disease. This observation raises questions about the underlying pathophysiological links between cardiovascular disease and PD. There is evidence for common mechanisms in the areas of glucose metabolism, cellular stress, lipid metabolism, and inflammation. On the other hand, smoking and total/low-density lipoprotein cholesterol appear to have opposite associations with cardiovascular disease and PD. Thus, it is uncertain whether the treatment of cardiovascular risk factors will impact on the onset or progression of PD. The available data suggest that a nuanced approach is necessary to manage risk factors such as cholesterol levels once the associations are better understood. Ultimately, the choice of therapy may be tailored to a patient's comorbidity profile. This review presents the epidemiological evidence for both concordant and discordant associations between cardiovascular disease and PD, discusses the cellular and metabolic processes that may underlie these links, and explores the implications this has for patient care and future research. © 2019 International Parkinson and Movement Disorder Society.
Identifiants
pubmed: 31483535
doi: 10.1002/mds.27836
pmc: PMC6981000
mid: NIHMS1064967
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-74Subventions
Organisme : Department of Health
ID : 16/167/19
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : U01 NS082151
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS112008
Pays : United States
Informations de copyright
© 2019 International Parkinson and Movement Disorder Society.
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