Membrane Lipid Remodeling Takes Center Stage in Growth Factor Receptor-Driven Cancer Development.

Humans Intercellular Signaling Peptides and Proteins Lipid Metabolism Membrane Lipids Neoplasms Receptors, Growth Factor

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
03 09 2019
Historique:
entrez: 5 9 2019
pubmed: 5 9 2019
medline: 28 4 2020
Statut: ppublish

Résumé

Enhanced growth factor signaling is a hallmark of cancer, allowing cancer cells to thrive in a challenging environment. In this issue of Cell Metabolism, Bi et al. (2019) identify LPCAT1, a key membrane lipid remodeling enzyme, as a central link between genetically driven growth factor receptor expression, signaling, and tumor growth, highlighting lipid remodeling as a therapeutic target in cancer.

Identifiants

DOI: 10.1016/j.cmet.2019.08.016 PMID: 31484051
pubmed: 31484051
pii: S1550-4131(19)30445-0
doi: 10.1016/j.cmet.2019.08.016
pii:
doi:

Substances chimiques

Intercellular Signaling Peptides and Proteins 0
Membrane Lipids 0
Receptors, Growth Factor 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

407-408

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

Auteurs

Johannes V Swinnen (JV)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address: j.swinnen@kuleuven.be.

Jonas Dehairs (J)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium.

Ali Talebi (A)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, LKI - Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Membrane Lipid Remodeling Takes Center Stage...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Membrane Lipid Remodeling Takes Center Stage...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Membrane Lipid Remodeling Takes Center Stage...
questionsmedicales.fr › Lipides › Lipides membranaires › Membrane Lipid Remodeling Takes Center Stage...
questionsmedicales.fr › Tumeurs › Membrane Lipid Remodeling Takes Center Stage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Membrane Lipid Remodeling Takes Center Stage...