Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.

Alphavirus / drug effects Animals Antibodies, Monoclonal / pharmacology Arthritis / pathology CRISPR-Cas Systems / genetics Chikungunya Fever / metabolism Chikungunya virus / drug effects Drosophila Proteins / metabolism Drosophila melanogaster / drug effects Immunoglobulins / deficiency Inflammation / pathology Membrane Proteins / deficiency Mice, Inbred C57BL Mutation / genetics
alphavirus arthritis mice pathogenesis receptor

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
03 09 2019
Historique:
received: 09 05 2019
revised: 18 07 2019
accepted: 29 07 2019
entrez: 5 9 2019
pubmed: 5 9 2019
medline: 15 9 2020
Statut: ppublish

Résumé

Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. To determine its role in pathogenesis, we generated mice with mutant Mxra8 alleles: an 8-nucleotide deletion that produces a truncated, soluble form (Mxra8

Identifiants

DOI: 10.1016/j.celrep.2019.07.105 PMID: 31484075 PMC: PMC6745702
pubmed: 31484075
pii: S2211-1247(19)31021-6
doi: 10.1016/j.celrep.2019.07.105
pmc: PMC6745702
mid: NIHMS1539073
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Drosophila Proteins 0
Immunoglobulins 0
Membrane Proteins 0
Mxra8 protein, mouse 0

Types de publication

Case Reports Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2647-2658.e5

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI123348
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR073752
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095436
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143673
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114816
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Références

Cell. 2001 Apr 6;105(1):137-48
pubmed: 11301009
J Virol. 2001 Nov;75(21):10118-31
pubmed: 11581380
Cell. 1975 Oct;6(2):215-22
pubmed: 1182802
J Virol. 1992 Aug;66(8):4992-5001
pubmed: 1385835
Glia. 2003 Dec;44(3):190-204
pubmed: 14603461
Gene. 2004 Apr 14;330:85-92
pubmed: 15087127
Virology. 2005 Feb 20;332(2):511-8
pubmed: 15680416
Nat Med. 2005 May;11(5):522-30
pubmed: 15852016
J Virol. 2006 Jan;80(2):737-49
pubmed: 16378976
Vector Borne Zoonotic Dis. 2006 Winter;6(4):325-37
pubmed: 17187566
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3312-7
pubmed: 17360644
PLoS Pathog. 2007 Jun;3(6):e89
pubmed: 17604450
J Cell Physiol. 2008 Sep;216(3):603-14
pubmed: 18366072
Nature. 2010 Dec 2;468(7324):709-12
pubmed: 21124458
Am J Pathol. 2011 Jan;178(1):32-40
pubmed: 21224040
Anim Biotechnol. 2011 Apr;22(2):51-63
pubmed: 21500107
J Virol. 2011 Sep;85(18):9327-33
pubmed: 21752915
Cell Host Microbe. 2011 Aug 18;10(2):97-104
pubmed: 21843867
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16026-31
pubmed: 21896745
J Bone Miner Res. 2012 Sep;27(9):2024-34
pubmed: 22492581
J Insect Physiol. 2013 Feb;59(2):159-70
pubmed: 22824741
J Med Virol. 2012 Nov;84(11):1757-70
pubmed: 22997079
J Immunol. 2013 Jan 1;190(1):259-69
pubmed: 23209328
Cardiovasc Res. 2013 Apr 1;98(1):73-82
pubmed: 23386276
PLoS Negl Trop Dis. 2013;7(2):e2050
pubmed: 23409203
J Virol. 2013 May;87(10):5697-706
pubmed: 23487448
PLoS Pathog. 2013 Mar;9(3):e1003232
pubmed: 23555248
Am J Trop Med Hyg. 2013 Jun;88(6):1170-9
pubmed: 23568285
PLoS Pathog. 2013;9(4):e1003312
pubmed: 23637602
J Virol. 2013 Dec;87(24):13878-88
pubmed: 24131709
J Virol. 2014 Mar;88(5):2385-97
pubmed: 24371059
J Virol. 2014 Jun;88(12):6862-72
pubmed: 24696480
J Virol. 2014 Nov;88(21):12180-92
pubmed: 25142598
Science. 2015 Nov 27;350(6264):1096-101
pubmed: 26472758
Cell. 2015 Nov 19;163(5):1095-1107
pubmed: 26553503
J Virol. 2016 Apr 14;90(9):4745-4756
pubmed: 26912616
Cell Rep. 2016 Aug 2;16(5):1326-1338
pubmed: 27452455
PLoS Pathog. 2017 Dec 15;13(12):e1006748
pubmed: 29244871
Osteoarthritis Cartilage. 2018 Jul;26(7):945-953
pubmed: 29702220
Nature. 2018 May;557(7706):570-574
pubmed: 29769725
Cell Host Microbe. 2018 Jul 11;24(1):57-68.e3
pubmed: 29934091
Vaccine. 1986 Sep;4(3):157-62
pubmed: 3020820
Inflamm Bowel Dis. 2019 Apr 11;25(5):853-861
pubmed: 30534988
Sci Immunol. 2019 Feb 22;4(32):null
pubmed: 30796092
Cell. 2019 Jun 13;177(7):1725-1737.e16
pubmed: 31080061
Cell. 2019 Jun 13;177(7):1714-1724.e12
pubmed: 31080063
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10648-52
pubmed: 7479858
J Virol. 1995 Mar;69(3):1621-7
pubmed: 7853497
Cell. 1995 Feb 24;80(4):621-30
pubmed: 7867069
Arch Virol Suppl. 1994;9:473-84
pubmed: 7913360
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9095-9
pubmed: 8415660
J Virol. 1996 Mar;70(3):2069-73
pubmed: 8627739
J Virol. 1997 Feb;71(2):1558-66
pubmed: 8995682
J Virol. 1998 Sep;72(9):7357-66
pubmed: 9696832
EMBO J. 1998 Aug 17;17(16):4585-93
pubmed: 9707418

Auteurs

Rong Zhang (R)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.

James T Earnest (JT)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Arthur S Kim (AS)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Emma S Winkler (ES)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Pritesh Desai (P)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Lucas J Adams (LJ)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Gaowei Hu (G)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Christopher Bullock (C)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Beth Gold (B)

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Sara Cherry (S)

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Michael S Diamond (MS)

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Togaviridae › Alphavirus › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Arthrite › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Togaviridae › Infections à alphavirus › Fièvre chikungunya › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Togaviridae › Alphavirus › Virus du chikungunya › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Expression of the Mxra8 Receptor Promotes...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Expression of the Mxra8 Receptor Promotes...