Thrombomodulin and Thrombopoietin, Two Biomarkers of Hemostasis, Are Positively Associated with Adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a Population-Based Cross-Sectional Study.
Academies and Institutes
Adult
Biomarkers
Cross-Sectional Studies
Data Collection
Diet
Female
Guidelines as Topic
Hemostasis
/ physiology
Humans
Life Style
Male
Middle Aged
Neoplasms
/ prevention & control
Risk Factors
Surveys and Questionnaires
Thrombomodulin
/ blood
Thrombopoietin
/ blood
United States
WCRF/AICR recommendations
cancer prevention
coagulation
fibrinogen
lifestyle
thrombomodulin
thrombopoietin
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
03 Sep 2019
03 Sep 2019
Historique:
received:
03
08
2019
revised:
22
08
2019
accepted:
27
08
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
19
2
2020
Statut:
epublish
Résumé
A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in a population-based study. Cross-sectional baseline data from 2267 randomly selected participants of EPIC-Heidelberg (age range 35-65 years) was used. Fibrinogen, glycoprotein IIb/IIIa, P-selectin, thrombomodulin (TM), and thrombopoietin (TPO) were measured in baseline plasma samples. A score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention was created. Associations between the WCRF/AICR score as well as its individual components and hemostatic biomarkers were analyzed by linear regression models. Multivariable-adjusted geometric means (95% confidence intervals) of TM and TPO were higher with greater adherence to the WCRF/AICR recommendations (TM, lowest vs. highest score category: 2.90 (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL,
Identifiants
pubmed: 31484340
pii: nu11092067
doi: 10.3390/nu11092067
pmc: PMC6770787
pii:
doi:
Substances chimiques
Biomarkers
0
Thrombomodulin
0
Thrombopoietin
9014-42-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Cancer Research Fund International
ID : 2015/1418
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