Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
10
11
2018
accepted:
10
05
2019
pubmed:
6
9
2019
medline:
31
1
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
To investigate whether women and men with Parkinson disease (PD) differ in their biochemical and clinical responses to long-term treatment with inosine. The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) trial enrolled 75 people with early PD and baseline serum urate below 6 mg/dL and randomized them to 3 double-blinded treatment arms: oral placebo or inosine titrated to produce mild (6.1-7.0 mg/dL) or moderate (7.1-8.0 mg/dL) serum urate elevation for up to 2 years. Parkinsonism, serum urate, and plasma antioxidant capacity were measured at baseline and repeatedly on treatment; CSF urate was assessed once, at 3 months. Here in secondary analyses results are stratified by sex. Inosine produced an absolute increase in average serum urate from baseline that was 50% greater in women (3.0 mg/dL) than in men (2.0 mg/dL), consistent with expected lower baseline levels in women. Similarly, only among women was CSF urate significantly greater on mild or moderate inosine (+87% [ Inosine produced greater increases in serum and CSF urate in women compared to men in the SURE-PD trial, consistent with the study's design and with preliminary evidence for slower clinical decline in early PD among women treated with urate-elevating doses of inosine. NCT00833690. This study provides Class II evidence that inosine produced greater urate elevation in women than men and may slow PD progression in women.
Identifiants
pubmed: 31484712
pii: WNL.0000000000008194
doi: 10.1212/WNL.0000000000008194
pmc: PMC6814412
doi:
Substances chimiques
Biomarkers
0
Uric Acid
268B43MJ25
Inosine
5A614L51CT
Banques de données
ClinicalTrials.gov
['NCT00833690']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1328-e1338Subventions
Organisme : NINDS NIH HHS
ID : U01 NS090259
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 American Academy of Neurology.
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