The expression of PD-L1 in salivary gland carcinomas.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 09 2019
04 09 2019
Historique:
received:
17
10
2018
accepted:
21
08
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
5
11
2020
Statut:
epublish
Résumé
Objective was to analyze the role of PD-L1 and its relation to demographic, patho-clinical and outcome parameters in salivary gland carcinoma (SGC) patients. Patients treated for salivary gland carcinomas between 1994 and 2010 were included. A retrospective chart review for baseline characteristics, pathohistological, clinical and outcome data was performed. Immunohistochemistry for PD-L1 was performed using tissue microarrays. PD-L1 expression was assessed in tumor cells and tumor-infiltrating immune cells (TIIC) and statistical analysis with regard to baseline and outcome data was performed. Expression of PD-L1 (by means ≥1% of the cells with PD-L1 positivity) was present in the salivary gland carcinoma cells of 17%, in the TIIC of 20% and in both tumor cells and TIIC of 10% the patients. PD-L1 expression in tumor cells and both tumor cells and TIIC was related to tumor grading (p = 0.035 and p = 0.031, respectively). A trend towards higher grading was also seen for PD-L1 expression in TIICs (p = 0.058). Patients with salivary duct carcinomas and PD-L1 expressing TIICs showed a significantly worse DFS and OS (p = 0.022 and p = 0.003, respectively), those with both tumor cells and TIIC expressing PD-L1 a significantly worse DFS (p = 0.030). PD-L1 expression is present in 17% and 20% of salivary gland carcinoma cells and TIIC. Ten percent of the patient showed a PD-L1 positivity in both tumor cells and TIIC. This is related to high tumor grading and therefore might be a negative prognostic factor.
Identifiants
pubmed: 31484986
doi: 10.1038/s41598-019-49215-9
pii: 10.1038/s41598-019-49215-9
pmc: PMC6726636
doi:
Substances chimiques
B7-H1 Antigen
0
Biomarkers, Tumor
0
CD274 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12724Références
Immunol Lett. 2006 Feb 15;102(2):222-8
pubmed: 16236366
Sci Transl Med. 2012 Mar 28;4(127):127ra37
pubmed: 22461641
Strahlenther Onkol. 2017 Nov;193(11):961-970
pubmed: 28828496
Otolaryngol Head Neck Surg. 2003 Dec;129(6):720-5
pubmed: 14663441
Laryngoscope Investig Otolaryngol. 2018 Apr 19;3(3):182-190
pubmed: 30062133
Neoplasia. 2006 Mar;8(3):190-8
pubmed: 16611412
Clin Cancer Res. 2005 Apr 15;11(8):2947-53
pubmed: 15837746
Cancer Immunol Res. 2016 Aug;4(8):679-87
pubmed: 27312343
Cancer Res Treat. 2016 Apr;48(2):527-36
pubmed: 26511814
Cancer Immunol Res. 2013 Jul;1(1):54-63
pubmed: 24416729
J Mol Med (Berl). 2003 May;81(5):281-7
pubmed: 12721664
Oral Oncol. 2014 Jul;50(7):627-32
pubmed: 24819861
Nat Rev Cancer. 2016 May;16(5):275-87
pubmed: 27079802
J Oral Pathol Med. 2016 Oct;45(9):655-663
pubmed: 27037970
J Clin Pathol. 2003 Dec;56(12):914-8
pubmed: 14645349
Ann Pathol. 2017 Feb;37(1):79-89
pubmed: 28111039
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12293-7
pubmed: 12218188
Cancer. 2005 Jun 15;103(12):2526-33
pubmed: 15900577
Lancet Oncol. 2011 Aug;12(8):815-24
pubmed: 21147032
Oral Dis. 2002 Sep;8(5):229-40
pubmed: 12363107
Arch Oral Biol. 2017 Nov;83:55-62
pubmed: 28711734
J Surg Oncol. 2016 Jul;114(1):36-43
pubmed: 27111278
Cancer Control. 2014 Jul;21(3):231-7
pubmed: 24955707
J Otolaryngol Head Neck Surg. 2016 May 16;45(1):32
pubmed: 27184361
Cancer Immunol Res. 2014 Apr;2(4):361-70
pubmed: 24764583
Int J Radiat Oncol Biol Phys. 1997 Jan 1;37(1):79-85
pubmed: 9054880
Acta Otolaryngol. 2002 Oct;122(7):758-64
pubmed: 12484654
Oral Oncol. 2014 Nov;50(11):e64-6
pubmed: 25218000
Cancer. 1981 Feb 15;47(4):645-8
pubmed: 7194729
Ann Surg Oncol. 2016 Jun;23(6):2038-45
pubmed: 26790669
Cancer. 1984 Sep 15;54(6):1062-9
pubmed: 6088017
J Oral Pathol Med. 2018 Aug;47(7):683-690
pubmed: 29719073
Hum Pathol. 2016 Jan;47(1):52-63
pubmed: 26527522
Nat Med. 2002 Aug;8(8):793-800
pubmed: 12091876
Arch Pathol Lab Med. 2009 Nov;133(11):1763-74
pubmed: 19886710
Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):103-11
pubmed: 15629600
Br J Dermatol. 2017 May;176(5):1354-1356
pubmed: 27516151
J Cutan Pathol. 2016 Aug;43(8):663-70
pubmed: 27153517
Cancer Res. 2013 Jan 1;73(1):128-38
pubmed: 23135914
Pathologe. 2016 Nov;37(6):557-567
pubmed: 27510417
Oral Oncol. 2017 Aug;71:41-46
pubmed: 28688689
Otolaryngol Head Neck Surg. 2016 Jun;154(6):1041-6
pubmed: 26980918
Int J Cancer. 2016 Jul 15;139(2):396-403
pubmed: 26945902
Cancer Res. 2013 Mar 15;73(6):1733-41
pubmed: 23288508
BMC Cancer. 2018 Feb 6;18(1):156
pubmed: 29409471