Human papillomavirus type 16 causes a defined subset of conjunctival in situ squamous cell carcinomas.
Journal
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 1530-0285
Titre abrégé: Mod Pathol
Pays: United States
ID NLM: 8806605
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
05
2019
accepted:
16
07
2019
revised:
16
07
2019
pubmed:
6
9
2019
medline:
15
12
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
Squamous cell carcinoma of the conjunctiva is associated with a number of risk factors, including HIV infection, iatrogenic immunosuppression and atopy. In addition, several studies have suggested an involvement of HPV, based on the presence of viral DNA, but did not establish whether there was active infection or evidence of causal disease association. In this manuscript, 31 cases of conjunctival in situ squamous cell carcinoma were classified as HPV DNA-positive or -negative, before being analysed by immunohistochemistry to establish the distribution of viral and cellular biomarkers of HPV gene expression. Our panel included p16
Identifiants
pubmed: 31485010
doi: 10.1038/s41379-019-0350-5
pii: S0893-3952(22)00947-4
pmc: PMC6930848
mid: EMS83753
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-90Subventions
Organisme : Medical Research Council
ID : MC_PC_13050
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U117584278
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S024409/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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