Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios Are Correlated with Complicated Diverticulitis and Hinchey Classification: A Simple Tool to Assess Disease Severity in the Emergency Department.
Journal
Emergency medicine international
ISSN: 2090-2840
Titre abrégé: Emerg Med Int
Pays: Egypt
ID NLM: 101567070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
02
2019
accepted:
22
07
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
6
9
2019
Statut:
epublish
Résumé
Rapid identification of patients with complications related to acute diverticulitis who require urgent intervention in the emergency department (ED) is essential. The aim of our study was to determine the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting severity of diverticulitis as assessed by Hinchey classification. We performed a single retrospective study in EMMS Nazareth Hospital from 4/2014 to 4/2018. Patients were categorized into two groups: group A with mild to moderate complicated diverticulitis (Hinchey 1-2) and group B with severe complicated diverticulitis (Hinchey 3-4). Two hundred twenty-five patients were included. Two hundred seven patients were in group A, and 18 patients were in group B. On univariate analysis, age, NLR, and PLR correlated with advanced Hinchey classification and disease severity (stages 3-4) (OR 1.038, 95% CI 1.001-1.076, The NLR and PLR independently associated with diverticulitis severity and positively correlated with advanced Hinchey classification. This simple available laboratory tool can be implemented into clinical practice to optimize patient management.
Sections du résumé
BACKGROUND AND AIM
OBJECTIVE
Rapid identification of patients with complications related to acute diverticulitis who require urgent intervention in the emergency department (ED) is essential. The aim of our study was to determine the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting severity of diverticulitis as assessed by Hinchey classification.
PATIENTS AND METHODS
METHODS
We performed a single retrospective study in EMMS Nazareth Hospital from 4/2014 to 4/2018. Patients were categorized into two groups: group A with mild to moderate complicated diverticulitis (Hinchey 1-2) and group B with severe complicated diverticulitis (Hinchey 3-4).
RESULTS
RESULTS
Two hundred twenty-five patients were included. Two hundred seven patients were in group A, and 18 patients were in group B. On univariate analysis, age, NLR, and PLR correlated with advanced Hinchey classification and disease severity (stages 3-4) (OR 1.038, 95% CI 1.001-1.076,
CONCLUSION
CONCLUSIONS
The NLR and PLR independently associated with diverticulitis severity and positively correlated with advanced Hinchey classification. This simple available laboratory tool can be implemented into clinical practice to optimize patient management.
Identifiants
pubmed: 31485352
doi: 10.1155/2019/6321060
pmc: PMC6710754
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6321060Déclaration de conflit d'intérêts
The authors declare no conflicts of interest regarding this manuscript.
Références
Lancet. 2004 Feb 21;363(9409):631-9
pubmed: 14987890
Int J Surg. 2007 Feb;5(1):27-30
pubmed: 17386911
J Gastroenterol Hepatol. 2007 Sep;22(9):1360-8
pubmed: 17716342
Gastroenterology. 2009 Apr;136(4):1198-205
pubmed: 19185583
J Clin Gastroenterol. 2010 Nov-Dec;44(10):702-6
pubmed: 20485187
Crit Care. 2010;14(5):R192
pubmed: 21034463
Clin Transl Oncol. 2011 Jul;13(7):499-503
pubmed: 21775277
PLoS One. 2011;6(10):e26125
pubmed: 22022533
Liver Int. 2012 Feb;32(2):297-302
pubmed: 22097893
Gastroenterology. 2012 Feb;142(2):205-7
pubmed: 22185897
Int J Surg. 2012;10(3):157-62
pubmed: 22361307
Biomarkers. 2012 May;17(3):216-22
pubmed: 22424597
Int J Colorectal Dis. 2012 Oct;27(10):1347-57
pubmed: 22460305
Hepatology. 2012 Nov;56(5):1751-9
pubmed: 22707395
Int Surg. 2012 Oct-Dec;97(4):299-304
pubmed: 23294069
J Gastrointest Surg. 2013 Apr;17(4):675-81
pubmed: 23371356
Ann Lab Med. 2013 Mar;33(2):105-10
pubmed: 23482854
Int J Lab Hematol. 2013 Jun;35(3):254-61
pubmed: 23590652
Clin Gastroenterol Hepatol. 2013 Dec;11(12):1609-13
pubmed: 23856358
PLoS One. 2013 Aug 15;8(8):e72349
pubmed: 23977288
Clin Appl Thromb Hemost. 2015 Mar;21(2):172-6
pubmed: 24322278
Br J Cancer. 2014 May 13;110(10):2524-30
pubmed: 24675383
Am Surg. 2014 Apr;80(4):391-5
pubmed: 24887672
Scand J Gastroenterol. 2015 May;50(5):536-41
pubmed: 25665622
Dig Surg. 2017;34(3):227-232
pubmed: 27941316
PLoS One. 2017 Nov 1;12(11):e0187629
pubmed: 29091955
Euroasian J Hepatogastroenterol. 2017 Jan-Jun;7(1):11-16
pubmed: 29201765
Medicine (Baltimore). 2018 Jun;97(26):e11138
pubmed: 29952958
Adv Surg. 1978;12:85-109
pubmed: 735943