Self-management for adults with epilepsy: Aggregate Managing Epilepsy Well Network findings on depressive symptoms.
depression
epilepsy
quality of life
seizures
self-management
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
07
03
2019
revised:
05
07
2019
accepted:
05
07
2019
pubmed:
6
9
2019
medline:
15
4
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
To assess depressive symptom outcomes in a pooled sample of epilepsy self-management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB). Five prospective RCTs involving 453 adults with epilepsy compared self-management intervention (n = 232) versus treatment as usual or wait-list control outcomes (n = 221). Depression was assessed with the nine-item Patient Health Questionnaire. Other variables included age, gender, race, ethnicity, education, income, marital status, seizure frequency, and quality of life. Follow-up assessments were collapsed into a visit 2 and a visit 3; these were conducted postbaseline. Mean age was 43.5 years (SD = 12.6), nearly two-thirds were women, and nearly one-third were African American. Baseline sample characteristics were mostly similar in the self-management intervention group versus controls. At follow-up, the self-management group had a significantly greater reduction in depression compared to controls at visit 2 (P < .0001) and visit 3 (P = .0002). Quality of life also significantly improved in the self-management group at visit 2 (P = .001) and visit 3 (P = .005). Aggregate MEW DB analysis of five RCTs found depressive symptom severity and quality of life significantly improved in individuals randomized to self-management intervention versus controls. Evidence-based epilepsy self-management programs should be made more broadly available in neurology practices.
Identifiants
pubmed: 31486072
doi: 10.1111/epi.16322
pmc: PMC7370538
mid: NIHMS1592221
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1921-1931Subventions
Organisme : NCCDPHP CDC HHS
ID : U48 DP005030
Pays : United States
Informations de copyright
Wiley Periodicals, Inc. © 2019 International League Against Epilepsy.
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