Trophoblasts promote induction of a regulatory phenotype in B cells that can protect against detrimental T cell-mediated inflammation.
B cells
inflammation
regulatory phenotype
spheroid
trophoblast
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
25
06
2019
revised:
25
08
2019
accepted:
29
08
2019
pubmed:
6
9
2019
medline:
21
8
2020
entrez:
6
9
2019
Statut:
ppublish
Résumé
A successful outcome to pregnancy is critically dependent on the initiation of maternal immune tolerance before embryo implantation. Cells of embryonic origin that come in contact with the uterine microenvironment can exert influence over the phenotype and function of immune cells to facilitate robust implantation; however, what influence they may have on B cells remains unknown. In this study, we investigate the effect of human trophoblast cells on B-cell phenotype and the subsequent effect on peri-implantation events. We cultured purified human B cells with the first-trimester human trophoblast cell line Swan 71 to investigate trophoblast-B-cell interactions and utilized trophoblast spheroids in an in vitro implantation model of migration and invasion. Trophoblast-educated B cells or TE-B cells were found to consist of B cells in committed lineages such as plasmablasts and memory B cells, as well as increased proportions in subsets of CD24 We posit that trophoblast-mediated education of B cells leads to their acquisition of properties capable of modulating inflammation in the uterine environment during the peri-implantation period.
Identifiants
pubmed: 31487409
doi: 10.1111/aji.13187
pmc: PMC8232043
mid: NIHMS1713709
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13187Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145829
Pays : United States
Organisme : Department of Obstetrics and Gynecology, Yale School of Medicine
Pays : International
Organisme : National Health and Medical Research Council
ID : APP1012386
Pays : International
Organisme : National Health and Medical Research Council
ID : APP1020984
Pays : International
Organisme : Research Training Program Domestic (RTPd) Scholarship
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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