Combined antiretroviral therapy for HIV and the risk of hypertensive disorders of pregnancy: A systematic review.


Journal

Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 21 12 2018
revised: 18 04 2019
accepted: 17 05 2019
pubmed: 6 9 2019
medline: 20 2 2020
entrez: 6 9 2019
Statut: ppublish

Résumé

To assess if there is a relationship between use of combined antiretroviral therapy among pregnant women living with HIV and hypertensive disorders of pregnancy (HDP). Due to the heterogeneity of study designs in the literature and the utilization of different outcome measures in regards to assessing the presence of HDP, a systematic review was performed. ClinicalTrials.gov and MEDLINE, via PubMed, EMBASE, Scopus, CINAHL, ProQuest Dissertations & Theses Global, EBSCOHost, DARE, and the Cochrane Library, were queried from January 1997 to October 2017. Studies were included if they reported HDP and focused on pregnant women living with HIV who used combined antiretroviral therapy. The Cochrane Collaboration's tool for assessment of risk of bias and the U.S. Preventive Services Task Force grading scale were used to assess the studies. Of 1055 abstracts, 28 articles met inclusion criteria. The data are marked by multiple biases and poor study design. All studies demonstrate an increased risk of HDP among pregnant women living with HIV who used combined antiretroviral therapy when compared to seropositive pregnant women not using antiretroviral therapy. Three studies suggest protease inhibitors may be associated with a higher risk of HDP. Despite all studies indicating a higher frequency of HDP among pregnant women living with HIV using combined antiretroviral therapy when compared with seropositive pregnant women not using antiretroviral therapy, the quality of the studies is mixed, necessitating further research.

Identifiants

pubmed: 31487638
pii: S2210-7789(18)30766-9
doi: 10.1016/j.preghy.2019.05.015
pmc: PMC6733581
mid: NIHMS1532751
pii:
doi:

Substances chimiques

Anti-HIV Agents 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

178-190

Subventions

Organisme : NICHD NIH HHS
ID : K12 HD050121
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD078153
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050409
Pays : United States

Informations de copyright

Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

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Auteurs

Ashish Premkumar (A)

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, 250 E. Superior Street, Chicago, IL 60611, USA. Electronic address: ashish.premkumar@northwestern.edu.

Annie M Dude (AM)

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, 250 E. Superior Street, Chicago, IL 60611, USA.

Lisa B Haddad (LB)

Department of Gynecology and Obstetrics, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303, USA.

Lynn M Yee (LM)

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Feinberg School of Medicine, Northwestern University, 250 E. Superior Street, Chicago, IL 60611, USA.

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Classifications MeSH