Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay.
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
09
05
2019
accepted:
02
09
2019
pubmed:
7
9
2019
medline:
28
4
2021
entrez:
7
9
2019
Statut:
ppublish
Résumé
Peripheral T-cell lymphoma comprises a heterogeneous group of mature non-Hodgkin lymphomas. Their diagnosis is challenging, with up to 30% of cases remaining unclassifiable and referred to as "not otherwise specified". We developed a reverse transcriptase-multiplex ligation-dependent probe amplification gene expression profiling assay to differentiate the main T-cell lymphoma entities and to study the heterogeneity of the "not specified" category. The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one Epstein-Barr virus-related transcript, and variants of
Identifiants
pubmed: 31488561
pii: haematol.2019.226647
doi: 10.3324/haematol.2019.226647
pmc: PMC7271600
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1582-1592Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright© 2020 Ferrata Storti Foundation.
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