Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids.
Hyperinsulinaemia
Insulin secretion
Insulin sensitivity
Minimal model
Plasma amino acids
Prediabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
04
07
2019
accepted:
29
07
2019
pubmed:
7
9
2019
medline:
28
5
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia. Non-obese (BMI < 30 kg/m Thirteen per cent of individuals had impaired fasting glucose (IFG; n = 14) or impaired glucose tolerance (IGT; n = 19), allowing comparisons across the continuum of insulin responses within the spectrum of normoglycaemia and prediabetes. BMI (~24 kg/m Hyperinsulinaemia within normoglycaemic young, non-obese adults manifests due to increased insulin secretion and reduced insulin clearance. Individual phenotypic characterisation revealed that the most hyperinsulinaemic were more similar to individuals with IGT than IFG, suggesting that hyperinsulinaemic individuals may be on the continuum toward IGT. Furthermore, plasma branched-chain amino acids may not be an effective biomarker in identifying hyperinsulinaemia and insulin resistance in young non-obese adults.
Identifiants
pubmed: 31489455
doi: 10.1007/s00125-019-04990-y
pii: 10.1007/s00125-019-04990-y
pmc: PMC6861536
doi:
Substances chimiques
Amino Acids
0
Blood Glucose
0
Insulin
0
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2310-2324Références
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