Effect of spirulina and silicon-enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats.
Animal Feed
Animals
Diet
Dietary Supplements
Fatty Liver
/ prevention & control
Glucose Tolerance Test
Lipid Metabolism
/ drug effects
Lipids
/ blood
Liver
/ chemistry
Male
Metabolic Syndrome
/ prevention & control
Mitochondria
/ drug effects
Mitochondria, Liver
/ drug effects
Mitochondria, Muscle
/ drug effects
Random Allocation
Rats
Rats, Zucker
Silicon
/ chemistry
Spirulina
Zucker rat
mitochondrial activity
obesity disorders
oxidative stress
silicon
spirulina
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
19
02
2019
revised:
24
04
2019
accepted:
05
05
2019
entrez:
7
9
2019
pubmed:
7
9
2019
medline:
18
9
2020
Statut:
ppublish
Résumé
The use of Spirulina platensis (Sp) as a functional food was suggested decades ago. Biological incorporation of Silicon (Si) into Sp increases its bioavailability for potential food supplement applications. This work aimed at determining the effects of Sp and Si-enriched Sp (Sp+Si) on metabolic syndrome features in Zucker fatty rats. Thirty Zucker fatty rats were divided into three groups and supplemented with placebo or Sp or Sp+Si croquettes for 12 weeks. Food consumption, glucose intolerance, hepatic steatosis, and mitochondrial and oxidative stress were determined. Zucker fatty rats exhibited several hepatic metabolic alterations as well as mitochondrial and oxidative stress perturbations. The intake of Sp increased plasma TG levels and decreased the hepatic NADPH oxidase activity and ameliorated transitorily the glucose intolerance. However, Si-spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets, or durations of diet intake should be undertaken to confirm or infirm these results. PRACTICAL APPLICATIONS: Glucose intolerance and hepatic steatosis, two major components of metabolic syndrome, are increasing and becomes a major public health issue. Use of Spirulina platensis (Sp) as a functional food was suggested as a protein-dense food source. Bioavailable silicon (Si) may be an essential nutrient for higher animals, including humans. Sp but not Sp+Si decreased liver NADPH oxidase activity and improved transitorily glucose tolerance. This is the first study where Sp and Sp+Si effect on glucose intolerance is reported in Zucker rat. Other experiments should be undertaken to confirm or infirm invalidate the beneficial effects of Sp+Si supplement in the metabolic syndrome features.
Substances chimiques
Lipids
0
Silicon
Z4152N8IUI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12979Informations de copyright
© 2019 Wiley Periodicals, Inc.
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