Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells.
Antineoplastic Agents
/ pharmacology
Cell Line, Tumor
Dose-Response Relationship, Drug
Enzyme Inhibitors
/ pharmacology
Gene Expression
Gentamicins
/ pharmacology
Humans
Lipid Metabolism
/ drug effects
Sphingomyelin Phosphodiesterase
/ antagonists & inhibitors
Sphingomyelins
/ metabolism
Stomach Neoplasms
/ drug therapy
cancer
drug target
lipid
sphingomyelin
sphingomyelinase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Sep 2019
06 Sep 2019
Historique:
received:
01
08
2019
revised:
29
08
2019
accepted:
03
09
2019
entrez:
7
9
2019
pubmed:
7
9
2019
medline:
6
2
2020
Statut:
epublish
Résumé
Emerging literature implicates acid sphingomyelinase in tumor sensitivity/resistance to anticancer treatments. Gentamicin is a drug commonly used as an antimicrobial but its serendipity effects have been shown. Even though many evidences on the role of gentamicin in cancer have been reported, its mechanism of action is poorly understood. Here, we explored acid sphingomyelinase as a possible new target of gentamicin in cancer. Since gastric cancer is one of the most common cancers and represents the second cause of death in the world, we performed the study in NCI-N87 gastric cancer cell line. The effect of the drug resulted in the inhibition of cell proliferation, including a reduction of cell number and viability, in the decrease of MIB-1 proliferative index as well as in the upregulation of cyclin-dependent kinase inhibitor 1A and 1B (
Identifiants
pubmed: 31489901
pii: ijms20184375
doi: 10.3390/ijms20184375
pmc: PMC6770866
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Enzyme Inhibitors
0
Gentamicins
0
Sphingomyelins
0
Sphingomyelin Phosphodiesterase
EC 3.1.4.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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