Diabetes in relation to Barrett's esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett's and Esophageal Adenocarcinoma Consortium.
Barrett esophagus
diabetes
epidemiology
esophageal adenocarcinoma
meta-analysis
Journal
Cancer
ISSN: 1097-0142
Titre abrégé: Cancer
Pays: United States
ID NLM: 0374236
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
12
03
2019
revised:
22
05
2019
accepted:
09
07
2019
pubmed:
7
9
2019
medline:
4
6
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinoma (EA) cases, 1938 esophagogastric junction adenocarcinoma (EGJA) cases, 1728 Barrett's esophagus (BE) cases, and 16,354 controls. Logistic regression was used to estimate study-specific odds ratios (ORs) and 95% CIs for self-reported diabetes in association with EA, EGJA, and BE. Adjusted ORs were then combined using random-effects meta-analysis. Diabetes was associated with a 34% increased risk of EA (OR, 1.34; 95% CI, 1.00-1.80; I Diabetes was associated with increased EA and EGJA risk, which was confined to individuals with regurgitation symptoms. Lack of an association between diabetes and BE suggests that diabetes may influence progression of BE to cancer.
Sections du résumé
BACKGROUND
Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear.
METHODS
Data were harmonized across 13 studies in the International Barrett's and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinoma (EA) cases, 1938 esophagogastric junction adenocarcinoma (EGJA) cases, 1728 Barrett's esophagus (BE) cases, and 16,354 controls. Logistic regression was used to estimate study-specific odds ratios (ORs) and 95% CIs for self-reported diabetes in association with EA, EGJA, and BE. Adjusted ORs were then combined using random-effects meta-analysis.
RESULTS
Diabetes was associated with a 34% increased risk of EA (OR, 1.34; 95% CI, 1.00-1.80; I
CONCLUSIONS
Diabetes was associated with increased EA and EGJA risk, which was confined to individuals with regurgitation symptoms. Lack of an association between diabetes and BE suggests that diabetes may influence progression of BE to cancer.
Identifiants
pubmed: 31490550
doi: 10.1002/cncr.32444
pmc: PMC7001889
mid: NIHMS1043015
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4210-4223Subventions
Organisme : NCI NIH HHS
ID : R01 CA001833
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA109193
Pays : United States
Organisme : Health Research Board (Dublin, Ireland)
Pays : International
Organisme : NIH HHS
ID : U01CA057949
Pays : United States
Organisme : NIH HHS
ID : R01CA116845
Pays : United States
Organisme : The Netherlands Cancer Foundation and the Dutch Digestive Disease Foundation
Pays : International
Organisme : NIH HHS
ID : K23DK079291
Pays : United States
Organisme : NIH HHS
ID : R01CA059636
Pays : United States
Organisme : NIH HHS
ID : R01CA030022
Pays : United States
Organisme : CSRD VA
ID : I01 CX000899
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA057949-03
Pays : United States
Organisme : Ulster Cancer Foundation
Pays : International
Organisme : NIH HHS
ID : U01CA199336
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA116845
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA199336
Pays : United States
Organisme : Kaiser Permanente Community Benefit Grant
Pays : International
Organisme : NIDDK NIH HHS
ID : K08 DK002697
Pays : United States
Organisme : NIH HHS
ID : R37CA041530
Pays : United States
Organisme : NIH HHS
ID : R01DK063616
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA057949
Pays : United States
Organisme : National Health and Medical Research Council
ID : 199600
Pays : International
Organisme : NCI NIH HHS
ID : U54 CA163059
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA030022
Pays : United States
Organisme : US Department of Veteran's Affairs Clinical Science Research and Development
ID : I01-CX000899
Pays : International
Organisme : NIH HHS
ID : U54CA163059
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010220-08
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK063616
Pays : United States
Organisme : NIH HHS
ID : R01CA001833
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK079291
Pays : United States
Organisme : California Tobacco Related Research Program
ID : 3RT-0122
Pays : International
Organisme : Queensland Cancer Fund
Pays : International
Organisme : NIH HHS
ID : K23DK059311
Pays : United States
Organisme : Research & Development Office (Belfast, Northern Ireland)
Pays : International
Organisme : NIH HHS
ID : R01CA109193
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK059311
Pays : United States
Organisme : NCI NIH HHS
ID : K07 CA222060
Pays : United States
Organisme : NIH HHS
ID : K08DK002697
Pays : United States
Organisme : National Health and Medical Research Council
Pays : International
Informations de copyright
© 2019 American Cancer Society.
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