Decreased circulating interleukin-33 concentration in Helicobacter pylori-infected patients with peptic ulcer: Evaluation of its association with a cytokine gene polymorphism, gender of patients and bacterial virulence factor CagA.
Gene polymorphism
Helicobacter pylori
IL-33
Peptic ulcer
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
15
02
2019
revised:
30
08
2019
accepted:
02
09
2019
pubmed:
7
9
2019
medline:
11
3
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
IL-33 has powerful immunoregulatory activities such as reinforcement of Th2 cell responses. The aim was to assess the circulating IL-33 levels and IL-33 rs1929992 polymorphism in H. pylori-infected peptic ulcer (PU) patients and asymptomatic (AS) subjects. Blood samples were obtained from 100 PU patients, 100 AS subjects and 100 uninfected individuals. Circulating IL-33 levels were detected by ELISA. After DNA extraction, the IL-33 rs1929992 polymorphism was determined using PCR-RFLP method. Serum IL-33 quantities were significantly lower in PU patients compared with AS and uninfected groups. IL-33 levels were higher in AS subjects compared with uninfected group. In PU, AS and uninfected groups, IL-33 levels were significantly higher in women than men. In PU and AS groups, the CagA
Identifiants
pubmed: 31491552
pii: S0882-4010(19)30304-3
doi: 10.1016/j.micpath.2019.103708
pii:
doi:
Substances chimiques
Antigens, Bacterial
0
Bacterial Proteins
0
IL33 protein, human
0
Interleukin-33
0
cagA protein, Helicobacter pylori
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103708Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.