Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron MRI contrast agent and investigation of its mechanism.
Acrylic Resins
/ chemistry
Animals
Calcium Channels, L-Type
/ metabolism
Cardiotoxicity
/ prevention & control
Cell Line
Cell Survival
/ drug effects
Dogs
Electrocardiography
Ferric Compounds
/ chemistry
Magnetic Resonance Imaging
/ methods
Male
Mice
Microscopy, Electron, Transmission
NAV1.5 Voltage-Gated Sodium Channel
/ metabolism
Nanoparticles
/ adverse effects
Rats
Cardiac toxicity
Ion balance
Iron oxide nanoparticles
Polyacrylic acid
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
23
04
2019
revised:
30
07
2019
accepted:
20
08
2019
pubmed:
7
9
2019
medline:
29
9
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
Polyelectrolyte modified iron oxide nanoparticles have great potential applications for clinical magnetic resonance imaging (MRI) and anemia treatments, however, possible associated heart toxicity is rarely reported. Here, polyacrylic acid (PAA)-coated Fe
Identifiants
pubmed: 31491561
pii: S0142-9612(19)30541-1
doi: 10.1016/j.biomaterials.2019.119442
pii:
doi:
Substances chimiques
Acrylic Resins
0
Calcium Channels, L-Type
0
Ferric Compounds
0
L-type calcium channel alpha(1C)
0
NAV1.5 Voltage-Gated Sodium Channel
0
ferric oxide
1K09F3G675
carbopol 940
4Q93RCW27E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119442Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.