Multifunctional nanoagents for ultrasensitive imaging and photoactive killing of Gram-negative and Gram-positive bacteria.
Anti-Bacterial Agents
/ chemistry
Bacterial Infections
/ drug therapy
Chlorophyllides
Disaccharides
/ chemistry
Gram-Negative Bacteria
/ drug effects
Gram-Positive Bacteria
/ drug effects
Humans
Nanoparticles
/ chemistry
Photochemotherapy
/ methods
Porphyrins
/ chemistry
Pseudomonas aeruginosa
/ drug effects
Radiation-Sensitizing Agents
/ chemistry
Staphylococcus aureus
/ drug effects
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 09 2019
06 09 2019
Historique:
received:
03
11
2018
accepted:
15
08
2019
entrez:
8
9
2019
pubmed:
8
9
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Simultaneous imaging and treatment of infections remains a major challenge, with most current approaches being effective against only one specific group of bacteria or not being useful for diagnosis. Here we develop multifunctional nanoagents that can potentially be used for imaging and treatment of infections caused by diverse bacterial pathogens. The nanoagents are made of fluorescent silicon nanoparticles (SiNPs) functionalized with a glucose polymer (e.g., poly[4-O-(α-D-glucopyranosyl)-D-glucopyranose]) and loaded with chlorin e6 (Ce6). They are rapidly internalized into Gram-negative and Gram-positive bacteria by a mechanism dependent on an ATP-binding cassette (ABC) transporter pathway. The nanoagents can be used for imaging bacteria by tracking the green fluorescence of SiNPs and the red fluorescence of Ce6, allowing in vivo detection of as few as 10
Identifiants
pubmed: 31492849
doi: 10.1038/s41467-019-12088-7
pii: 10.1038/s41467-019-12088-7
pmc: PMC6731231
doi:
Substances chimiques
Anti-Bacterial Agents
0
Chlorophyllides
0
Disaccharides
0
Porphyrins
0
Radiation-Sensitizing Agents
0
phytochlorin
5S2CCF3T1Z
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4057Références
Adv Mater. 2016 Dec;28(47):10567-10574
pubmed: 27529602
ACS Nano. 2011 Nov 22;5(11):8834-41
pubmed: 21967150
Adv Mater. 2015 Feb 11;27(6):1029-34
pubmed: 25377423
J Biol Chem. 1988 Jan 5;263(1):314-20
pubmed: 3275641
J Membr Biol. 2004 Jul 15;200(2):67-81
pubmed: 15520905
J Med Chem. 2014 Dec 26;57(24):10275-89
pubmed: 25419855
Nat Microbiol. 2018 Aug;3(8):847
pubmed: 30046176
ACS Nano. 2015 Jun 23;9(6):5958-67
pubmed: 26027458
Mol Microbiol. 2010 Sep;77(6):1354-66
pubmed: 20659291
Nat Mater. 2014 Jul;13(7):748-55
pubmed: 24813421
J Clin Invest. 2011 Jul;121(7):2768-80
pubmed: 21670497
Nanoscale. 2017 Dec 21;10(1):132-141
pubmed: 29135009
Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15152-5
pubmed: 26493283
Metallomics. 2009 Sep;1(5):409-17
pubmed: 21305145
J Biol Chem. 1993 Sep 5;268(25):18617-21
pubmed: 8360157
Nat Med. 2014 Mar;20(3):301-6
pubmed: 24487433
Nat Commun. 2014 Sep 17;5:4918
pubmed: 25230005
FEMS Microbiol Rev. 2015 Nov;39(6):892-916
pubmed: 26109599
Nat Commun. 2013;4:2584
pubmed: 24129412
Nat Commun. 2018 May 17;9(1):1969
pubmed: 29773788
Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14096-14101
pubmed: 25330976
Nat Med. 2004 Dec;10(12 Suppl):S122-9
pubmed: 15577930
ACS Nano. 2017 Jan 24;11(1):927-937
pubmed: 28027442
Front Biosci. 2003 May 01;8:s265-74
pubmed: 12700071
J Am Chem Soc. 2011 Mar 23;133(11):4132-9
pubmed: 21344925
Chem Sci. 2015 Dec 1;6(12):6971-6979
pubmed: 29861935
Nanoscale. 2017 Jun 8;9(22):7602-7611
pubmed: 28540373
J Am Chem Soc. 2016 Apr 13;138(14):4824-31
pubmed: 27010956
Acc Chem Res. 2011 Oct 18;44(10):1050-60
pubmed: 21919457
ACS Nano. 2014 Aug 26;8(8):7733-45
pubmed: 25093948
Science. 2006 Dec 1;314(5804):1464-7
pubmed: 17138901
ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2052-2058
pubmed: 28026159
J Bacteriol. 2005 Dec;187(24):8322-31
pubmed: 16321936
Nat Commun. 2018 Jan 9;9(1):129
pubmed: 29317632
ACS Nano. 2017 May 23;11(5):4428-4438
pubmed: 28350437
J Am Chem Soc. 2010 Sep 8;132(35):12349-56
pubmed: 20707350
Sci Transl Med. 2014 Oct 29;6(260):260ra149
pubmed: 25355699
J Biol Chem. 2002 Mar 29;277(13):11321-8
pubmed: 11796734
Nat Mater. 2011 Jul 17;10(8):602-7
pubmed: 21765397
J Am Chem Soc. 2010 May 12;132(18):6566-70
pubmed: 20405918
Nat Med. 2011 Aug 21;17(9):1142-6
pubmed: 21857652
Ann Microbiol (Paris). 1982 Jan;133A(1):153-9
pubmed: 7041738
Nat Biotechnol. 2007 Oct;25(10):1165-70
pubmed: 17891134
ACS Appl Mater Interfaces. 2018 Mar 28;10(12):9980-9987
pubmed: 29498260
J Am Chem Soc. 2016 May 25;138(20):6455-62
pubmed: 27139159
Res Microbiol. 2002 Sep;153(7):417-24
pubmed: 12405347
Nat Commun. 2018 Mar 2;9(1):917
pubmed: 29500445
Microbiol Mol Biol Rev. 1998 Mar;62(1):204-29
pubmed: 9529892
J Bacteriol. 2006 Jun;188(11):3911-22
pubmed: 16707683
PLoS One. 2010 Apr 27;5(4):e10349
pubmed: 20436965
Biomaterials. 2011 Sep;32(25):5855-62
pubmed: 21601920
Nat Commun. 2014 Nov 13;5:5427
pubmed: 25391809
Anal Biochem. 2005 Apr 1;339(1):69-72
pubmed: 15766712