Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy.

Animals Dose Fractionation, Radiation Humans Neoplasms / radiotherapy Organs at Risk / radiation effects Proton Therapy / methods Radiation Injuries / prevention & control Radiation Tolerance Rats
Minibeam radiation therapy Preclinical research Proton Radiothérapie par minifaisceaux Recherche préclinique

Journal

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
ISSN: 1769-6658
Titre abrégé: Cancer Radiother
Pays: France
ID NLM: 9711272

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 29 07 2019
accepted: 01 08 2019
pubmed: 9 9 2019
medline: 8 10 2019
entrez: 9 9 2019
Statut: ppublish

Résumé

In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so far will be presented for various spatially fractionated techniques GRID, micro- and minibeam radiation therapy. Recent results demonstrating that proton minibeam radiation therapy leads to an increase in normal tissues sparing will be discussed, which opens the door to a dose escalation in the tumour and a possibly efficient treatment of very radioresistant tumours.

Identifiants

DOI: 10.1016/j.canrad.2019.08.001 PMID: 31494038
pubmed: 31494038
pii: S1278-3218(19)30306-3
doi: 10.1016/j.canrad.2019.08.001
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

677-681

Informations de copyright

Copyright © 2019 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.

Auteurs

L De Marzi (L)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France; Institut Curie, university Paris Saclay, PSL Research university, Inserm U 1021-CNRS UMR 3347, Orsay, France. Electronic address: ludovic.demarzi@curie.fr.

C Nauraye (C)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

P Lansonneur (P)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

F Pouzoulet (F)

Institut Curie, RadeXp Platform, centre universitaire, 91405 Orsay, France.

A Patriarca (A)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

T Schneider (T)

IMNC-UMR 8165, CNRS, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Diderot, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Sud, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France.

C Guardiola (C)

IMNC-UMR 8165, CNRS, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Diderot, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Sud, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France.

H Mammar (H)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

R Dendale (R)

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

Y Prezado (Y)

IMNC-UMR 8165, CNRS, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Diderot, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France; UMR 8165, université de Paris Sud, 15, rue Georges-Clémenceau, 91405 Orsay cedex, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Dosimétrie en radiothérapie › Fractionnement de la dose d'irradiation › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Tumeurs › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Régions du corps › Organes à risque › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Protonthérapie › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Effets des rayonnements › Lésions radiques › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Phénomènes physiologiques › Radiotolérance › Spatial fractionation of the dose in proton...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Spatial fractionation of the dose in proton...