Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC.
Dopamine depletion
Flexibility
Learning
Transcranial direct current stimulation
tDCS
Journal
Brain stimulation
ISSN: 1876-4754
Titre abrégé: Brain Stimul
Pays: United States
ID NLM: 101465726
Informations de publication
Date de publication:
Historique:
received:
23
05
2019
revised:
27
08
2019
accepted:
28
08
2019
pubmed:
9
9
2019
medline:
6
6
2020
entrez:
9
9
2019
Statut:
ppublish
Résumé
Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning. A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility. Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition. Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.
Sections du résumé
BACKGROUND
Recent evidence suggests that transcranial direct current stimulation (tDCS) may interact with the dopaminergic system to affect cognitive flexibility. Objective/hypotheses: We examined whether putative reduction of dopamine levels through the acute phenylalanine/tyrosine depletion (APTD) procedure and excitatory anodal tDCS of the dorsolateral prefrontal cortex (dlPFC) are causally related to cognitive flexibility as measured by task switching and reversal learning.
METHOD
A double-blind, sham-controlled, randomised trial was conducted to test the effects of combining anodal tDCS and depletion of catecholaminergic precursor tyrosine on cognitive flexibility.
RESULTS
Anodal tDCS and tyrosine depletion had a significant effect on task switching, but not reversal learning. Whilst perseverative errors were significantly improved by anodal tDCS, the APTD impaired reaction times. Importantly, the combination of APTD and anodal tDCS resulted in cognitive performance which did not statistically differ to that of the control condition.
CONCLUSIONS
Our results suggest that the effects of tDCS on cognitive flexibility are modulated by dopaminergic tone.
Identifiants
pubmed: 31494070
pii: S1935-861X(19)30362-6
doi: 10.1016/j.brs.2019.08.016
pmc: PMC7116421
mid: EMS104579
pii:
doi:
Substances chimiques
Tyrosine
42HK56048U
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-108Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102584
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102584/Z/13/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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