The current state of omics technologies in the clinical management of asthma and allergic diseases.
Journal
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN: 1534-4436
Titre abrégé: Ann Allergy Asthma Immunol
Pays: United States
ID NLM: 9503580
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
11
07
2019
revised:
27
08
2019
accepted:
29
08
2019
pubmed:
9
9
2019
medline:
10
3
2020
entrez:
9
9
2019
Statut:
ppublish
Résumé
To review the state of omics science specific to asthma and allergic diseases and discuss the current and potential applicability of omics in clinical disease prediction, treatment, and management. Studies and reviews focused on the use of omics technologies in asthma and allergic disease research and clinical management were identified using PubMed. Publications were included based on relevance, with emphasis placed on the most recent findings. Omics-based research is increasingly being used to differentiate asthma and allergic disease subtypes, identify biomarkers and pathological mediators, predict patient responsiveness to specific therapies, and monitor disease control. Although most studies have focused on genomics and transcriptomics approaches, increasing attention is being placed on omics technologies that assess the effect of environmental exposures on disease initiation and progression. Studies using omics data to identify biological targets and pathways involved in asthma and allergic disease pathogenesis have primarily focused on a specific omics subtype, providing only a partial view of the disease process. Although omics technologies have advanced our understanding of the molecular mechanisms underlying asthma and allergic disease pathology, omics testing for these diseases are not standard of care at this point. Several important factors need to be addressed before these technologies can be used effectively in clinical practice. Use of clinical decision support systems and integration of these systems within electronic medical records will become increasingly important as omics technologies become more widely used in the clinical setting.
Identifiants
pubmed: 31494234
pii: S1081-1206(19)31049-X
doi: 10.1016/j.anai.2019.08.460
pmc: PMC6931133
mid: NIHMS1543658
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
550-557Subventions
Organisme : NICHD NIH HHS
ID : K12 HD043483
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI077930
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL087738
Pays : United States
Informations de copyright
Copyright © 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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