Increased CD68/TGFβ Co-expressing Microglia/ Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys.
Inflammation
Macaca mulatta
Microglia
Stroke
Transforming growth factor beta
Journal
Experimental neurobiology
ISSN: 1226-2560
Titre abrégé: Exp Neurobiol
Pays: Korea (South)
ID NLM: 101278187
Informations de publication
Date de publication:
31 Aug 2019
31 Aug 2019
Historique:
received:
09
03
2019
revised:
10
06
2019
accepted:
08
07
2019
entrez:
9
9
2019
pubmed:
9
9
2019
medline:
9
9
2019
Statut:
ppublish
Résumé
The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in rhesus monkeys. We measured infarct volume and neurological function by magnetic resonance imaging (MRI) and non-human primate stroke scale (NHPSS), respectively, to assess temporal changes following MCAO. Activated phagocytic microglia/macrophages were examined by immunohistochemistry in post-mortem brains (n=6 MCAO, n=2 controls) at 3 and 24 hours (acute stage), 2 and 4 weeks (subacute stage), and 4, and 20 months (chronic stage) following MCAO. We found that the infarct volume progressively decreased between 1 and 4 weeks following MCAO, in parallel with the neurological recovery. Greater presence of cluster of differentiation 68 (CD68)-expressing microglia/macrophages was detected in the infarct lesion in the subacute and chronic stage, compared to the acute stage. Surprisingly, 98~99% of transforming growth factor beta (TGFβ) was found co-localized with CD68-expressing cells. CD68-expressing microglia/macrophages, rather than CD206
Identifiants
pubmed: 31495075
pii: en.2019.28.4.458
doi: 10.5607/en.2019.28.4.458
pmc: PMC6751863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
458-473Références
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