Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
Amyloid β
Causal relationship
Plasma proteomics
Replication
SOMAscan assay
Tau
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
12
02
2019
revised:
11
06
2019
accepted:
23
06
2019
pubmed:
10
9
2019
medline:
1
9
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid. A panel of proteins (n = 44), along with age and apolipoprotein E (APOE) ε4, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve = 0.78) and the replication group (area under the curve = 0.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization. The results suggest that high-dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.
Identifiants
pubmed: 31495601
pii: S1552-5260(19)35118-0
doi: 10.1016/j.jalz.2019.06.4951
pmc: PMC6880298
pii:
doi:
Substances chimiques
Amyloid
0
Apolipoprotein E4
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1478-1488Subventions
Organisme : Medical Research Council
ID : MC_PC_17215
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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