Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid.
Alzheimer's disease
Biomarker
Dementia
Diagnosis
Epigenetics
Genetics
Meta-analysis
Pathophysiology
Prognosis
Systematic review
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
01
03
2019
revised:
13
06
2019
accepted:
23
06
2019
pubmed:
10
9
2019
medline:
1
9
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Several microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case-control studies remains inconclusive. A systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta-analyses on eligible data for brain, blood, and cerebrospinal fluid specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty. Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10 Our systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance.
Identifiants
pubmed: 31495604
pii: S1552-5260(19)35119-2
doi: 10.1016/j.jalz.2019.06.4952
pii:
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1468-1477Informations de copyright
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.