Functional Logic of Layer 2/3 Inhibitory Connectivity in the Ferret Visual Cortex.
Animals
Ferrets
GABAergic Neurons
/ physiology
Inhibitory Postsynaptic Potentials
/ physiology
Interneurons
/ physiology
Neocortex
/ physiology
Neural Inhibition
/ physiology
Neural Pathways
/ physiology
Neurons
/ physiology
Optogenetics
Patch-Clamp Techniques
Presynaptic Terminals
Visual Cortex
/ physiology
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
06 11 2019
06 11 2019
Historique:
received:
15
10
2018
revised:
29
05
2019
accepted:
01
08
2019
pubmed:
10
9
2019
medline:
31
3
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Understanding how cortical inhibition shapes circuit function requires identifying the connectivity rules relating the response properties of inhibitory interneurons and their postsynaptic targets. Here we explore the orientation tuning of layer 2/3 inhibitory inputs in the ferret visual cortex using a combination of in vivo axon imaging, functional input mapping, and physiology. Inhibitory boutons exhibit robust orientation-tuned responses with preferences that can differ significantly from the cortical column in which they reside. Inhibitory input fields measured with patterned optogenetic stimulation and intracellular recordings revealed that these inputs originate from a wide range of orientation domains, inconsistent with a model of co-tuned inhibition and excitation. Intracellular synaptic conductance measurements confirm that individual neurons can depart from a co-tuned regime. Our results argue against a simple rule for the arrangement of inhibitory inputs supplied by layer 2/3 circuits and suggest that heterogeneity in presynaptic inhibitory networks contributes to neural response properties.
Identifiants
pubmed: 31495646
pii: S0896-6273(19)30688-9
doi: 10.1016/j.neuron.2019.08.004
pmc: PMC6842115
mid: NIHMS1537465
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
451-457.e3Subventions
Organisme : NEI NIH HHS
ID : R01 EY006821
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY011488
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
J Neurophysiol. 2000 Aug;84(2):909-26
pubmed: 10938316
Nat Neurosci. 2016 Aug;19(8):1003-9
pubmed: 27294510
Nat Neurosci. 2005 Nov;8(11):1552-9
pubmed: 16222228
Science. 2015 Jul 3;349(6243):70-4
pubmed: 26138975
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3844-8
pubmed: 7731993
Nat Neurosci. 2005 Mar;8(3):372-9
pubmed: 15711543
Neuron. 2017 Dec 6;96(5):1127-1138.e4
pubmed: 29103806
Nat Neurosci. 2004 Oct;7(10):1113-22
pubmed: 15338009
Elife. 2016 Mar 24;5:
pubmed: 27011354
J Neurosci. 1997 Mar 15;17(6):2112-27
pubmed: 9045738
Neuron. 2017 Aug 30;95(5):1147-1159.e4
pubmed: 28858618
Curr Biol. 2007 Jul 3;17(13):R496-500
pubmed: 17610826
Biomed Eng Online. 2003 May 17;2:13
pubmed: 12801419
Front Neural Circuits. 2014 Mar 11;8:15
pubmed: 24653677
Nature. 2017 Jul 27;547(7664):449-452
pubmed: 28700575
Neuron. 2011 Mar 24;69(6):1188-203
pubmed: 21435562
Neuron. 2015 Jul 15;87(2):424-36
pubmed: 26182423
Neuron. 2011 Oct 20;72(2):231-43
pubmed: 22017986
Annu Rev Neurosci. 2004;27:419-51
pubmed: 15217339
Nat Neurosci. 2017 Jan;20(1):62-71
pubmed: 27798631
J Neurosci. 2013 Aug 21;33(34):13713-23
pubmed: 23966693
Elife. 2016 Aug 15;5:
pubmed: 27525487
Neuron. 2011 Aug 11;71(3):542-54
pubmed: 21835349
J Neurophysiol. 2009 May;101(5):2708-24
pubmed: 19225176
Nature. 2013 Jul 18;499(7458):295-300
pubmed: 23868258
J Neurosci. 2011 Sep 14;31(37):13260-71
pubmed: 21917809
Nat Neurosci. 2011 Jul 17;14(8):1045-52
pubmed: 21765421
J Neurosci Methods. 2007 May 15;162(1-2):8-13
pubmed: 17254636
Neuron. 2008 Apr 10;58(1):132-43
pubmed: 18400169
J Neurosci. 2011 Aug 24;31(34):12339-50
pubmed: 21865476
J Neurosci. 2012 Apr 18;32(16):5609-19
pubmed: 22514322
Nat Neurosci. 2011 Jan;14(1):100-7
pubmed: 21076426
Nature. 2018 Aug;560(7716):97-101
pubmed: 30046106
Nat Neurosci. 2016 Dec;19(12):1743-1749
pubmed: 27798629
Nature. 2003 Nov 27;426(6965):442-6
pubmed: 14647382
Neuron. 2005 Jan 6;45(1):133-45
pubmed: 15629708
J Neurosci. 1989 Jul;9(7):2432-42
pubmed: 2746337
Nature. 2016 Apr 21;532(7599):370-4
pubmed: 27018655
J Neurosci. 1994 Jan;14(1):409-41
pubmed: 8283248
PLoS One. 2013 Jun 14;8(6):e66332
pubmed: 23799092
J Neurosci Methods. 2017 Nov 1;291:83-94
pubmed: 28782629
Neuron. 2015 Jan 21;85(2):402-17
pubmed: 25611511
Nat Commun. 2013;4:2088
pubmed: 23800837
J Neurosci. 2013 Oct 23;33(43):17108-22
pubmed: 24155315
Neuron. 2017 Mar 8;93(5):1058-1065.e4
pubmed: 28279352
Nat Neurosci. 2010 Nov;13(11):1404-12
pubmed: 20953197
Nature. 2015 Feb 19;518(7539):399-403
pubmed: 25652823
Cereb Cortex. 2002 Feb;12(2):187-98
pubmed: 11739266
Nat Neurosci. 2003 Dec;6(12):1300-8
pubmed: 14625553
J Neurosci. 2009 Aug 19;29(33):10321-34
pubmed: 19692606
Neuron. 2014 Apr 16;82(2):474-85
pubmed: 24656931