Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study.
NF1
breast cancer
mammography screening
neurofibromatosis 1
prognosis
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
ISSN: 1530-0366
Titre abrégé: Genet Med
Pays: United States
ID NLM: 9815831
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
13
06
2019
accepted:
27
08
2019
pubmed:
10
9
2019
medline:
12
1
2021
entrez:
10
9
2019
Statut:
ppublish
Résumé
Neurofibromatosis 1 (NF1) is an autosomal dominant condition caused by pathogenic variants of the NF1 gene. A markedly increased risk of breast cancer is associated with NF1. We have determined the breast cancer survival and risk of contralateral breast cancer in NF1. We included 142 women with NF1 and breast cancer from five cohorts in Europe and 335 women without NF1 screened for other familial breast cancers. Risk of contralateral breast cancer and death were assessed by Kaplan-Meier analysis with delayed entry. One hundred forty-two women with NF1 were diagnosed for breast cancer at a median age of 46.9 years (range 27.0-84.3 years) and then followed up for 1235 person-years (mean = 8.70 years). Twelve women had contralateral breast cancer with a rate of 10.5 per 1000 years. Cumulative risk for contralateral breast cancer was 26.5% in 20 years. Five and 10-year all-cause survival was 64.9% (95% confidence interval [CI] = 54.8-76.8) and 49.8% (95%CI = 39.3-63.0). Breast cancer-specific 10-year survival was 64.2% (95% CI = 53.5-77.0%) compared with 91.2% (95% CI = 87.3-95.2%) in the non-NF1 age-matched population at increased risk of breast cancer. Women with NF1 have a substantial contralateral breast cancer incidence and poor survival. Early start of breast cancer screening may be a way to improve the survival.
Identifiants
pubmed: 31495828
doi: 10.1038/s41436-019-0651-6
pii: S1098-3600(21)01290-9
pmc: PMC7000349
doi:
Substances chimiques
NF1 protein, human
0
Neurofibromin 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
398-406Subventions
Organisme : Department of Health
ID : IS-BRC-1215-20007
Pays : United Kingdom
Organisme : Suomen Kulttuurirahasto
ID : -
Pays : International
Commentaires et corrections
Type : ErratumIn
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