Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview.


Journal

Orthopaedic surgery
ISSN: 1757-7861
Titre abrégé: Orthop Surg
Pays: Australia
ID NLM: 101501666

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 04 06 2019
revised: 04 07 2019
accepted: 08 07 2019
pubmed: 10 9 2019
medline: 20 3 2020
entrez: 10 9 2019
Statut: ppublish

Résumé

Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest bone graft (ICBG) is the "gold standard" for bone grafting. However, the limited availability and complications at donor sites resulted in seeking other options like allografts and bone graft substitutes. Demineralized bone matrix (DBM) is a form of allograft using acidic solution to remove mineral components, while leaving much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates, and some trace cell debris. It is an osteoconductive and osteoinductive biomaterial and is approved as a medical device for use in bone defects and spinal fusion. To pack consistently into the defect sites and stay firmly in the filling parts, DBM products have various forms combined with biocompatible viscous carriers, including sponges, strips, injectable putty, paste, and paste infused with chips. The present review aims to summarize the properties of various kind of viscous carriers and their clinical use combined with DBM in commercially available products. Given DBM'mercially available products. Given DBM;s long clinical track record and commercial accessibility in standard forms, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopaedic repair and regenerative medicine contexts are attractive.

Identifiants

pubmed: 31496049
doi: 10.1111/os.12509
pmc: PMC6819172
doi:

Substances chimiques

Biocompatible Materials 0
Bone Substitutes 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

725-737

Subventions

Organisme : Library of Tianjin Medical University

Informations de copyright

© 2019 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.

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Auteurs

Hao Zhang (H)

Department of Bone Tumor, Tianjin Hospital, Tianjin, China.
Graduate School, Tianjin Medical University, Tianjin, China.

Li Yang (L)

Graduate School, Tianjin Medical University, Tianjin, China.

Xiong-Gang Yang (XG)

Graduate School, Tianjin Medical University, Tianjin, China.

Feng Wang (F)

Graduate School, Tianjin Medical University, Tianjin, China.

Jiang-Tao Feng (JT)

Graduate School, Tianjin Medical University, Tianjin, China.

Kun-Chi Hua (KC)

Graduate School, Tianjin Medical University, Tianjin, China.

Qi Li (Q)

Beijing Wonderful Medical Biomaterial Co. Ltd., Beijing, China.

Yong-Cheng Hu (YC)

Department of Bone Tumor, Tianjin Hospital, Tianjin, China.

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Classifications MeSH