Portal vein thrombosis in cirrhosis: Why a well-known complication is still matter of debate.
Administration, Oral
Anticoagulants
/ administration & dosage
Disease Progression
Female
Humans
Hypertension, Portal
/ etiology
Liver Cirrhosis
/ complications
Patient Selection
Portal Vein
/ pathology
Portasystemic Shunt, Transjugular Intrahepatic
Prognosis
Prospective Studies
Time Factors
Treatment Outcome
Venous Thrombosis
/ etiology
Anticoagulation
Direct oral anticoagulants
Hypercoagulability
Liver cirrhosis
Portal vein thrombosis
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 Aug 2019
21 Aug 2019
Historique:
received:
05
05
2019
revised:
08
07
2019
accepted:
19
07
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
15
2
2020
Statut:
ppublish
Résumé
Portal vein thrombosis (PVT) represents a well-known complication during the natural course of liver cirrhosis (LC), ranging from asymptomatic cases to life-threating conditions related to portal hypertension and hepatic decompensation. Portal flow stasis, complex acquired hypercoagulable disorders and exogenous factors leading to endothelial dysfunction have emerged as key factors for PVT development. However, PVT occurrence remains unpredictable and many issues regarding its natural history, prognostic significance and treatment are still elusive. In particular although spontaneous resolution or disease stability occur in most cases of PVT, factors predisposing to disease progression or recurrence after spontaneous recanalization are not clarified as yet. Moreover, PVT impact on LC outcome is still debated, as PVT may represent itself a consequence of liver fibrosis and hepatic dysfunction progression. Anticoagulation and transjugular intrahepatic portosystemic shunt are considered safe and effective in this setting and are recommended in selected cases, even if the safer therapeutic option and the optimal therapy duration are still unknown. Nevertheless, their impact on mortality rates should be addressed more extensively. In this review we present the most debated questions regarding PVT, whose answers should come from prospective cohort studies and large sample-size randomized trials.
Identifiants
pubmed: 31496623
doi: 10.3748/wjg.v25.i31.4437
pmc: PMC6710174
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4437-4451Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Références
Hepatogastroenterology. 2001 May-Jun;48(39):818-22
pubmed: 11462931
Transplantation. 2001 Nov 15;72(9):1572-82
pubmed: 11707747
Endoscopy. 2002 Jul;34(7):535-8
pubmed: 12170404
Am J Transplant. 2002 Nov;2(10):934-8
pubmed: 12482145
Hepatology. 2003 Sep;38(3):599-612
pubmed: 12939586
J Hepatol. 2004 May;40(5):736-41
pubmed: 15094219
Hepatology. 2005 Feb;41(2):386-400
pubmed: 15660434
Eur J Gastroenterol Hepatol. 2005 Mar;17(3):339-43
pubmed: 15716659
Hepatology. 2005 Mar;41(3):553-8
pubmed: 15726661
World J Gastroenterol. 2006 Apr 7;12(13):2115-9
pubmed: 16610067
Hepatology. 2006 Jul;44(1):53-61
pubmed: 16799972
J Hepatol. 2007 Feb;46(2):286-94
pubmed: 17166617
Am J Transplant. 2009 Jan;9(1):192-200
pubmed: 19067664
Clin Liver Dis. 2009 Feb;13(1):117-126
pubmed: 19150316
Dig Dis Sci. 2010 Feb;55(2):529-34
pubmed: 19242796
Hepatology. 2009 May;49(5):1729-64
pubmed: 19399912
J Hepatol. 2009 Oct;51(4):682-9
pubmed: 19464747
J Am Coll Surg. 2009 May;208(5):896-903; discussion 903-5
pubmed: 19476857
J Gastroenterol Hepatol. 2010 Jan;25(1):116-21
pubmed: 19686413
J Clin Gastroenterol. 2010 Jul;44(6):448-51
pubmed: 19730112
J Thromb Haemost. 2010 Sep;8(9):1994-2000
pubmed: 20546119
Gut. 2011 Jun;60(6):846-52
pubmed: 21357252
N Engl J Med. 2011 Jul 14;365(2):147-56
pubmed: 21751907
Abdom Imaging. 2012 Jun;37(3):431-8
pubmed: 21904887
J Hepatol. 2012 Jul;57(1):203-12
pubmed: 22446690
Gastroenterology. 2012 Nov;143(5):1253-1260.e4
pubmed: 22819864
Radiology. 2012 Oct;265(1):124-32
pubmed: 22891357
World J Gastroenterol. 2012 Sep 28;18(36):5014-20
pubmed: 23049208
Transplantation. 2012 Dec 15;94(11):1145-53
pubmed: 23128996
Am J Gastroenterol. 2013 Apr;108(4):568-74
pubmed: 23381015
Thromb Haemost. 2013 Oct;110(4):626-7
pubmed: 23846289
Dig Liver Dis. 2014 Feb;46(2):152-6
pubmed: 24084343
Clin Res Hepatol Gastroenterol. 2014 Apr;38(2):155-63
pubmed: 24183545
Ann Surg. 2014 Apr;259(4):760-6
pubmed: 24299686
Hepatology. 2014 Jul;60(1):425-6
pubmed: 24395623
Heart. 2014 Apr;100(7):550-6
pubmed: 24476812
Transplant Rev (Orlando). 2014 Apr;28(2):92-101
pubmed: 24582320
Hepatology. 2015 Feb;61(2):738-9
pubmed: 24829112
Clin Appl Thromb Hemost. 2014 Oct;20(7):673-7
pubmed: 24917126
J Thromb Thrombolysis. 2015 Jul;40(1):54-60
pubmed: 25115839
J Pharmacol Exp Ther. 2014 Nov;351(2):288-97
pubmed: 25138021
Saudi J Gastroenterol. 2014 Sep-Oct;20(5):288-92
pubmed: 25253363
Hepatology. 2015 Feb;61(2):660-7
pubmed: 25284616
Z Gastroenterol. 2014 Oct;52(10):1175-7
pubmed: 25313630
Eur J Intern Med. 2015 Jan;26(1):23-9
pubmed: 25566699
Gastroenterol Res Pract. 2015;2015:480842
pubmed: 25810714
J Gastrointestin Liver Dis. 2015 Mar;24(1):51-9, 4 p following 59
pubmed: 25822434
Liver Transpl. 2015 Aug;21(8):1016-21
pubmed: 25845711
Eur J Gastroenterol Hepatol. 2015 Aug;27(8):914-9
pubmed: 25856686
Liver Transpl. 2015 Jul;21(7):944-52
pubmed: 25891227
Transplantation. 2015 Nov;99(11):2347-55
pubmed: 25905983
Saudi J Gastroenterol. 2015 May-Jun;21(3):165-74
pubmed: 26021776
World J Gastroenterol. 2015 Jul 14;21(26):8004-13
pubmed: 26185371
Eur J Gastroenterol Hepatol. 2016 Jan;28(1):82-9
pubmed: 26513611
J Hepatol. 2016 Jan;64(1):179-202
pubmed: 26516032
World J Hepatol. 2015 Nov 28;7(27):2774-80
pubmed: 26644821
Radiology. 2016 Jun;279(3):943-51
pubmed: 26653681
Liver Transpl. 2016 Mar;22(3):352-65
pubmed: 26684272
Dig Dis Sci. 2016 Jun;61(6):1721-7
pubmed: 26725062
Radiology. 2016 Feb;278(2):333-53
pubmed: 26789601
Hepat Mon. 2015 Dec 27;15(12):e26407
pubmed: 26977162
Intern Emerg Med. 2016 Dec;11(8):1059-1066
pubmed: 27026379
Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):722-729
pubmed: 27160816
Intern Emerg Med. 2016 Oct;11(7):959-67
pubmed: 27220954
Med Sci Monit. 2016 Jul 19;22:2528-50
pubmed: 27432511
Dig Liver Dis. 2016 Oct;48(10):1208-13
pubmed: 27470055
Gastroenterology. 2016 Oct;151(4):574-577.e3
pubmed: 27575821
Rev Esp Enferm Dig. 2016 Nov;108(11):716-720
pubmed: 27756145
Liver Int. 2017 May;37(5):694-699
pubmed: 27778440
Clin Mol Hepatol. 2016 Dec;22(4):499-502
pubmed: 27880998
Eur J Haematol. 2017 Apr;98(4):393-397
pubmed: 28009449
World J Hepatol. 2017 Jan 28;9(3):139-146
pubmed: 28217250
Liver Int. 2017 Aug;37(8):1251
pubmed: 28267885
Hepatol Res. 2018 Jan;48(1):51-58
pubmed: 28342265
Gastroenterology. 2017 Aug;153(2):480-487.e1
pubmed: 28479379
Liver Int. 2018 Jan;38(1):94-101
pubmed: 28632958
Liver Int. 2017 Oct;37(10):1574-1575
pubmed: 28675619
J Hepatol. 2017 Nov;67(5):950-956
pubmed: 28716745
Medicine (Baltimore). 2017 Oct;96(42):e8256
pubmed: 29049216
Clin Gastroenterol Hepatol. 2018 Jul;16(7):1146-1152.e4
pubmed: 29066371
Saudi J Gastroenterol. 2018 Jan-Feb;24(1):25-29
pubmed: 29451181
Edinb Med J. 1869 Jan;14(7):589-598
pubmed: 29639641
Gastroenterol Res Pract. 2018 Apr 18;2018:3287491
pubmed: 29849584
Thromb Haemost. 2018 Aug;118(8):1491-1506
pubmed: 30060258
Clin Transl Gastroenterol. 2018 Aug 15;9(8):176
pubmed: 30108204
Eur J Gastroenterol Hepatol. 2019 Jan;31(1):34-42
pubmed: 30188408
Aliment Pharmacol Ther. 2019 Jan;49(1):20-30
pubmed: 30450634
Cancers (Basel). 2018 Nov 16;10(11):null
pubmed: 30453547
Am J Gastroenterol. 2019 Feb;114(2):258-266
pubmed: 30538290
Thromb Haemost. 2019 Mar;119(3):496-499
pubmed: 30616246
Aliment Pharmacol Ther. 2019 Mar;49(5):582-588
pubmed: 30671978
Can J Gastroenterol Hepatol. 2019 Jan 8;2019:4383269
pubmed: 30792971
Dig Dis Sci. 2019 Sep;64(9):2671-2683
pubmed: 30852769
AJR Am J Roentgenol. 1995 Nov;165(5):1151-5
pubmed: 7572494
Dig Dis Sci. 1996 Jan;41(1):185-90
pubmed: 8565755
Thromb Haemost. 1997 Jan;77(1):44-7
pubmed: 9031447
Thromb Haemost. 1998 Apr;79(4):747-51
pubmed: 9569186