Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer.
GCN5
Histone acetyltransferases
SAGA complex
c-MYC
non-small cell lung cancer
oncoprotein
Journal
American journal of cancer research
ISSN: 2156-6976
Titre abrégé: Am J Cancer Res
Pays: United States
ID NLM: 101549944
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
05
2019
accepted:
03
07
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
10
9
2019
Statut:
epublish
Résumé
Lung cancer causes the highest mortality in cancer-related deaths. As these cancers often become resistant to existing therapies, definition of novel molecular targets is needed. Epigenetic modifiers may provide such targets. Recent reports suggest that the histone acetyltransferase (HAT) module within the transcriptional coactivator SAGA complex plays a role in cancer, creating a new link between epigenetic regulators and this disease. GCN5 serves as a coactivator for MYC target genes, and here we investigate links between GCN5 and c-MYC in non-small cell lung cancer (NSCLC). Our data indicate that both GCN5 and c-MYC proteins are upregulated in mouse and human NSCLC cells compared to normal lung epithelial cells. This trend is observable only at the protein level, indicating that this upregulation occurs post-transcriptionally. Human NSCLC tissue data provided by The Cancer Genome Atlas (TCGA) indicates that
Types de publication
Journal Article
Langues
eng
Pagination
1830-1845Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Déclaration de conflit d'intérêts
None.
Références
Nat Genet. 2000 Oct;26(2):229-32
pubmed: 11017084
J Biol Chem. 2002 Jun 28;277(26):23399-406
pubmed: 11973336
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81
pubmed: 12552134
EMBO Rep. 2003 Jun;4(6):575-80
pubmed: 12776177
EMBO Rep. 2003 May;4(5):484-90
pubmed: 12776737
Mol Cell Biol. 2004 Dec;24(24):10826-34
pubmed: 15572685
Nat Rev Drug Discov. 2006 Jan;5(1):37-50
pubmed: 16485345
Cancer Res. 2006 Apr 15;66(8):4198-207
pubmed: 16618742
EMBO J. 2006 Jun 21;25(12):2723-34
pubmed: 16724113
Dev Dyn. 2007 Jun;236(6):1547-57
pubmed: 17440986
Oncogene. 2007 Aug 13;26(37):5329-40
pubmed: 17694076
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14917-22
pubmed: 17848523
Dev Dyn. 2008 Apr;237(4):928-40
pubmed: 18330926
Dev Growth Differ. 2008 Jun;50(5):321-30
pubmed: 18430026
N Engl J Med. 2008 Sep 25;359(13):1367-80
pubmed: 18815398
J Biol Chem. 2008 Dec 5;283(49):33808-15
pubmed: 18838386
Mol Cell Biol. 2009 Jan;29(1):266-80
pubmed: 18936164
J Med Chem. 2009 Jan 22;52(2):530-6
pubmed: 19099397
J Biol Chem. 2009 Apr 3;284(14):9411-7
pubmed: 19218239
Mol Cell. 2009 Aug 14;35(3):352-64
pubmed: 19683498
J Clin Invest. 2010 Apr;120(4):1298-309
pubmed: 20237410
Curr Opin Cell Biol. 2010 Jun;22(3):374-82
pubmed: 20363118
PLoS One. 2010 Apr 22;5(4):e10312
pubmed: 20421987
Mol Cancer Res. 2011 Jan;9(1):25-35
pubmed: 21115742
EMBO J. 2011 Jan 19;30(2):249-62
pubmed: 21131905
Clin Cancer Res. 2011 Mar 15;17(6):1481-9
pubmed: 21148746
Cell Cycle. 2011 Jan 1;10(1):57-67
pubmed: 21200143
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Clin Cancer Res. 2012 Jan 15;18(2):475-86
pubmed: 22068659
PLoS One. 2012;7(6):e39456
pubmed: 22745758
Theory Biosci. 2012 Dec;131(4):281-5
pubmed: 22872506
Genes Dev. 2013 Mar 1;27(5):504-13
pubmed: 23475959
J Biol Chem. 2013 May 17;288(20):14510-21
pubmed: 23543735
Lancet. 2013 Aug 24;382(9893):709-19
pubmed: 23972814
Biochim Biophys Acta. 2014 May;1839(5):395-405
pubmed: 24705139
Ecancermedicalscience. 2012 Nov 14;6:ed16
pubmed: 24883085
Cold Spring Harb Perspect Med. 2014 Jun 02;4(6):null
pubmed: 24890832
J Cancer Res Clin Oncol. 2014 Dec;140(12):2021-5
pubmed: 25012251
Mol Cell Proteomics. 2014 Nov;13(11):2896-910
pubmed: 25106422
Epigenomics. 2014 Jun;6(3):329-39
pubmed: 25111486
Mol Cell Proteomics. 2015 Jan;14(1):162-76
pubmed: 25381059
Genes Dev. 2015 Apr 15;29(8):803-16
pubmed: 25877919
Int J Mol Sci. 2015 Sep 10;16(9):21897-910
pubmed: 26378521
Mol Oncol. 2016 Feb;10(2):317-29
pubmed: 26628108
Mol Cancer Res. 2016 Mar;14(3):287-95
pubmed: 26631572
Gene Expr. 2015;16(4):187-96
pubmed: 26637399
Oncotarget. 2016 Mar 8;7(10):11332-48
pubmed: 26870991
Clin Epigenetics. 2016 May 26;8:59
pubmed: 27231488
Cell Biosci. 2016 Aug 02;6:47
pubmed: 27486509
Cell Rep. 2016 Oct 18;17(4):1193-1205
pubmed: 27760321
J Med Chem. 2017 Jan 26;60(2):695-709
pubmed: 28002667
Elife. 2017 Jan 19;6:
pubmed: 28100396
J Natl Cancer Inst. 2017 Jun 1;109(6):
pubmed: 28376145
Genes (Basel). 2017 Apr 05;8(4):
pubmed: 28379189
Oncotarget. 2017 Apr 18;8(16):26269-26280
pubmed: 28412741
Cell. 2017 Jul 27;170(3):564-576.e16
pubmed: 28753430
J Cancer. 2017 Jul 20;8(12):2277-2281
pubmed: 28819431
Nat Genet. 2017 Dec;49(12):1779-1784
pubmed: 29083409
Stem Cell Reports. 2018 Jan 9;10(1):287-299
pubmed: 29249668
J Cell Mol Med. 2018 Nov;22(11):5333-5345
pubmed: 30079588
Nat Commun. 2018 Nov 2;9(1):4610
pubmed: 30389920
JCO Clin Cancer Inform. 2018 Dec;2:1-12
pubmed: 30652536
Nucleic Acids Res. 2019 Apr 23;47(7):3383-3394
pubmed: 30715476
Nature. 1983 Nov 10-16;306(5939):194-6
pubmed: 6646201
Mol Cell Biol. 1999 Jan;19(1):1-11
pubmed: 9858526