AntimiR-155 Cyclic Peptide-PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
27 Aug 2019
27 Aug 2019
Historique:
received:
10
06
2019
accepted:
25
07
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
10
9
2019
Statut:
epublish
Résumé
Efficient delivery of nucleic acids into cells still remains a great challenge. Peptide nucleic acids (PNAs) are DNA analogues with a neutral backbone and are synthesized by solid phase peptide chemistry. This allows a straightforward synthetic route to introduce a linear short peptide (a.k.a. cell-penetrating peptide) to the PNA molecule as a means of facilitating cellular uptake of PNAs. Herein, we have devised a synthetic route in which a cyclic peptide is prepared on a solid support and is extended with the PNA molecule, where all syntheses are accomplished on the solid phase. This allows the conjugation of the cyclic peptide to the PNA molecule with the need of only one purification step after the cyclic peptide-PNA conjugate (C
Identifiants
pubmed: 31497713
doi: 10.1021/acsomega.9b01697
pmc: PMC6714607
doi:
Types de publication
Journal Article
Langues
eng
Pagination
13954-13961Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Org Lett. 2002 Nov 14;4(23):4013-6
pubmed: 12423074
Nucleic Acids Res. 2005 Nov 30;33(21):6837-49
pubmed: 16321967
J Gene Med. 2006 Oct;8(10):1262-73
pubmed: 16900561
Nucleic Acids Res. 2007;35(13):4495-502
pubmed: 17584792
Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29
pubmed: 18037527
Mol Ther. 2008 Jun;16(6):1120-8
pubmed: 18443602
Mol Ther. 2008 Sep;16(9):1624-9
pubmed: 18545222
Bioconjug Chem. 2008 Aug;19(8):1526-34
pubmed: 18646838
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9
pubmed: 18806224
Nucleic Acids Res. 2008 Nov;36(20):6418-28
pubmed: 18842625
Bioconjug Chem. 2009 Aug 19;20(8):1523-30
pubmed: 19591462
Science. 1991 Dec 6;254(5037):1497-500
pubmed: 1962210
Cardiovasc Res. 2010 Feb 1;85(3):444-53
pubmed: 19815563
Mol Ther. 2010 Jan;18(1):198-205
pubmed: 19844193
Biochim Biophys Acta. 2010 Dec;1798(12):2296-303
pubmed: 20170628
J Infect Dis. 2010 Jun 15;201(12):1822-30
pubmed: 20438352
Mol Ther. 2010 Oct;18(10):1822-9
pubmed: 20700113
RNA. 2011 May;17(5):933-43
pubmed: 21441346
Oncogene. 2012 Feb 23;31(8):1024-33
pubmed: 21765469
Cancer Gene Ther. 2012 Jan;19(1):30-7
pubmed: 21997230
Int J Oncol. 2012 Jul;41(1):228-34
pubmed: 22470130
ACS Chem Biol. 2013 Feb 15;8(2):345-52
pubmed: 23113581
Nucleic Acid Ther. 2013 Apr;23(2):109-17
pubmed: 23308382
Mol Ther Nucleic Acids. 2012 Aug 14;1:e38
pubmed: 23344180
Oncol Rep. 2013 Nov;30(5):2111-8
pubmed: 23970205
Mol Ther Nucleic Acids. 2014 Oct 28;3:e206
pubmed: 25350581
Nature. 2015 Feb 5;518(7537):107-10
pubmed: 25409146
Tumour Biol. 2016 Apr;37(4):5413-26
pubmed: 26563369
Chem Commun (Camb). 2016 Feb 7;52(11):2405-7
pubmed: 26735489
Biochemistry. 2016 May 10;55(18):2601-12
pubmed: 27089101
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7
pubmed: 27621445
Curr Opin Chem Biol. 2017 Jun;38:24-29
pubmed: 28249193
Drug Des Devel Ther. 2017 Feb 28;11:533-545
pubmed: 28280301
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4213-4218
pubmed: 28373570
Bioconjug Chem. 2017 Dec 20;28(12):3036-3042
pubmed: 29211451
Mol Ther Nucleic Acids. 2017 Dec 15;9:111-119
pubmed: 29246289
Cancer Metastasis Rev. 2018 Mar;37(1):33-44
pubmed: 29282605
Bioconjug Chem. 2018 Sep 19;29(9):2892-2898
pubmed: 30130094
Nucleic Acid Ther. 2019 Feb;29(1):1-12
pubmed: 30307373
Biosens Bioelectron. 2019 Jul 15;137:271-278
pubmed: 31121464
Nature. 1993 Oct 7;365(6446):566-8
pubmed: 7692304