A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
28
02
2019
accepted:
28
06
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
10
9
2019
Statut:
epublish
Résumé
Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. The transcriptional coactivator with PDZ-binding motif (TAZ; encoded by WW domain-containing transcription regulator 1 [
Identifiants
pubmed: 31497743
doi: 10.1002/hep4.1405
pii: HEP41405
pmc: PMC6719739
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1221-1234Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK116620
Pays : United States
Commentaires et corrections
Type : ErratumIn
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