The impact of cannabis use on intracarotid amobarbital testing.
Cannabis
Intracarotid amobarbital test
Intractable epilepsy
Marijuana
Wada test
Journal
Epilepsy & behavior reports
ISSN: 2589-9864
Titre abrégé: Epilepsy Behav Rep
Pays: United States
ID NLM: 101750909
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
05
2019
revised:
20
05
2019
accepted:
01
06
2019
entrez:
10
9
2019
pubmed:
10
9
2019
medline:
10
9
2019
Statut:
epublish
Résumé
Chronic cannabis use impacts memory functioning, even while users are not acutely intoxicated. The impact of cannabis use on Wada or intracarotid amobarbital testing (IAT) has not previously been described. We reviewed cannabis consumption in epilepsy patients undergoing IAT during pre-surgical work-up. Of 58 patients reviewed, 16 patients (28%) indicated regular use. During IAT, five regular cannabis users with suspected temporal lobe epilepsy exhibited poor memory while testing their presumptively healthy temporal lobe (i.e., the side opposite that targeted for epilepsy surgery), indicating the potential for an amnestic syndrome post-operatively. It was suspected that the pattern of IAT results for these patients was attributable to the deleterious impact of cannabis use on cognition. Thus, three of the five underwent repeat IAT after a period of enforced abstinence. On repeat IAT, each of the three patients exhibited improved memory performance while testing their healthy temporal lobe, suggesting that the healthy temporal lobe of each mediated sufficient memory ability to allow for epilepsy surgery. These findings raised concerns that frequent cannabis use may alter IAT results, leading to incorrect assessments regarding potential post-operative cognitive deficits, and led to a mandate at our institution that patients must stop cannabis use before IAT.
Identifiants
pubmed: 31497755
doi: 10.1016/j.ebr.2019.100328
pii: S2589-9864(19)30073-5
pii: 100328
pmc: PMC6719280
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100328Déclaration de conflit d'intérêts
The authors affirm that they do not have conflicts of interest.
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