Mediation by Placental DNA Methylation of the Association of Prenatal Maternal Smoking and Birth Weight.
DNA methylation
epigenetics
mediation
smoking
Journal
American journal of epidemiology
ISSN: 1476-6256
Titre abrégé: Am J Epidemiol
Pays: United States
ID NLM: 7910653
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
14
11
2018
revised:
17
04
2019
accepted:
22
04
2019
pubmed:
10
9
2019
medline:
4
4
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Prenatal maternal smoking is a risk factor for lower birth weight. We performed epigenome-wide association analyses of placental DNA methylation (DNAm) at 720,077 cytosine-phosphate-guanine (CpG) sites and prenatal maternal smoking among 441 mother-infant pairs (2010-2014) and evaluated whether DNAm mediates the association between smoking and birth weight using mediation analysis. Mean birth weight was 3,443 (standard deviation, 423) g, and 38 mothers (8.6%) reported smoking at a mean of 9.4 weeks of gestation. Prenatal maternal smoking was associated with a 175-g lower birth weight (95% confidence interval (CI): -305.5, -44.8) and with differential DNAm of 71 CpGs in placenta, robust to latent-factor adjustment reflecting cell types (Bonferroni-adjusted P < 6.94 × 10-8). Of the 71 CpG sites, 7 mediated the association between prenatal smoking and birth weight (on MDS2, PBX1, CYP1A2, VPRBP, WBP1L, CD28, and CDK6 genes), and prenatal smoking × DNAm interactions on birth weight were observed for 5 CpG sites. The strongest mediator, cg22638236, was annotated to the PBX1 gene body involved in skeletal patterning and programming, with a mediated effect of 301-g lower birth weight (95% CI: -543, -86) among smokers but no mediated effect for nonsmokers (β = -38 g; 95% CI: -88, 9). Prenatal maternal smoking might interact with placental DNAm at specific loci, mediating the association with lower infant birth weight.
Identifiants
pubmed: 31497855
pii: 5566169
doi: 10.1093/aje/kwz184
pmc: PMC6825837
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1878-1886Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL125858
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Organisme : Canadian Institute of Health Research
ID : MOP 115071
Pays : International
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : ErratumIn
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Diabetes. 2018 Aug;67(8):1673-1683
pubmed: 29752424
Environ Health Perspect. 2012 Oct;120(10):1425-31
pubmed: 22851337
Environ Health Perspect. 2012 Feb;120(2):296-302
pubmed: 22005006
Environ Mol Mutagen. 2014 Apr;55(3):171-83
pubmed: 24449392
Nat Methods. 2016 May;13(5):443-5
pubmed: 27018579
Mol Cell. 2015 Jan 22;57(2):247-260
pubmed: 25557551
Epigenetics. 2017;12(10):875-885
pubmed: 28820654
Addict Behav. 2005 May;30(4):853-7
pubmed: 15833588
Mech Dev. 2002 Feb;111(1-2):99-113
pubmed: 11804782
Arch Toxicol. 2008 Oct;82(10):667-715
pubmed: 18618097
Metabolism. 2010 Oct;59(10):1481-90
pubmed: 20462615
Am J Hum Genet. 2016 Apr 7;98(4):680-96
pubmed: 27040690
Annu Rev Nutr. 2007;27:363-88
pubmed: 17465856
Endocr Rev. 2006 Apr;27(2):141-69
pubmed: 16434511
Eur J Epidemiol. 2015 Oct;30(10):1115-8
pubmed: 26438385
Cell Physiol Biochem. 2016;39(3):919-38
pubmed: 27513464
Reprod Toxicol. 2011 Apr;31(3):363-73
pubmed: 21256208
Epigenomics. 2017 Mar;9(3):253-265
pubmed: 28234025
Hum Mol Genet. 2015 Aug 1;24(15):4464-79
pubmed: 25935004
Clin Epigenetics. 2016 Nov 16;8:118
pubmed: 27891191
Int J Obes (Lond). 2008 Feb;32(2):201-10
pubmed: 18278059
Placenta. 2005 May;26(5):361-71
pubmed: 15850640
Sci Rep. 2018 Apr 4;8(1):5654
pubmed: 29618728
Environ Health Perspect. 2017 Apr;125(4):511-526
pubmed: 28362264
Expert Rev Clin Pharmacol. 2012 Sep;5(5):569-85
pubmed: 23121279
Pediatr Res. 2012 Jul;72(1):101-7
pubmed: 22441375
Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E443-56
pubmed: 24368670
Early Hum Dev. 2007 Nov;83(11):699-706
pubmed: 17900829
Int J Epidemiol. 2015 Aug;44(4):1224-37
pubmed: 25862628
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Environ Health Perspect. 2017 Aug 29;125(8):087022
pubmed: 28934725
J Transl Med. 2017 Jan 4;15(1):5
pubmed: 28052772
Epidemiology. 2014 Sep;25(5):749-61
pubmed: 25000145
Development. 2001 Sep;128(18):3543-57
pubmed: 11566859
Pediatrics. 2004 Apr;113(4 Suppl):1007-15
pubmed: 15060193
Cells Tissues Organs. 2011;194(2-4):146-50
pubmed: 21597276
Nature. 2016 Oct 13;538(7624):248-252
pubmed: 27680694
Biochem Pharmacol. 1996 Jul 26;52(2):379-83
pubmed: 8694864
Hum Mol Genet. 2015 Apr 15;24(8):2201-17
pubmed: 25552657
Nat Rev Genet. 2018 Mar;19(3):129-147
pubmed: 29129922
Am J Obstet Gynecol. 2002 Mar;186(3):531-7
pubmed: 11904619
BMC Genomics. 2014 Oct 27;15:941
pubmed: 25348288
BMJ Open. 2016 Feb 03;6(2):e010031
pubmed: 26842272
Bioinformatics. 2016 Jan 15;32(2):286-8
pubmed: 26424855
Epigenetics. 2014 Nov;9(11):1473-84
pubmed: 25482056
Mol Cell. 2013 Nov 7;52(3):459-67
pubmed: 24140421
Clin Epigenetics. 2018 Aug 23;10(1):110
pubmed: 30139389
Int J Epidemiol. 2016 Oct;45(5):1644-1655
pubmed: 27591263
Epigenetics. 2011 Nov;6(11):1284-94
pubmed: 21937876
Carcinogenesis. 2013 Sep;34(9):2010-6
pubmed: 23644744
Am J Respir Crit Care Med. 2017 Sep 15;196(6):745-755
pubmed: 28422514
Sci Rep. 2017 Mar 21;7(1):288
pubmed: 28325913
Science. 2013 Dec 20;342(6165):1518-21
pubmed: 24357321
BMC Genomics. 2018 Apr 25;19(1):290
pubmed: 29695247