The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting-state fcMRI study.
CONN toolbox
hippocampus
resting-state functional connectivity
semantic memory
semantic variant of primary progressive aphasia
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
26
02
2019
revised:
15
08
2019
accepted:
23
08
2019
pubmed:
10
9
2019
medline:
13
6
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
The goal of the study was to determine whether the semantic variant of primary progressive aphasia (svPPA) affects the intrinsic connectivity network anchored to left and right anterior hippocampus, but spares the posterior hippocampus. A resting-state functional connectivity MRI (rs-fcMRI) study was conducted in a group of patients with svPPA and in controls, using a seed-to-voxel approach. In comparison to controls, massively reduced connectivity was found in the anterior hippocampus, mainly the left one, for svPPA patients but not in the left or right posterior hippocampus. In svPPA, the anterior hippocampus showed reduced functional connectivity with regions implicated in the semantic memory network. Significant correlation was also found between the functional connectivity strength of the left anterior hippocampus and the ventromedial cortex, and performance in semantic tasks. These findings indicate that the functional disconnection of the anterior hippocampus may be a promising in vivo biomarker of svPPA and illustrate the role of this hippocampal subregion in the semantic memory system.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1127-1132Subventions
Organisme : Alzheimer's Society of Canada
ID : 1420
Pays : International
Organisme : Brain Canada Foundation
Pays : International
Organisme : "Consortium d'imagerie en neuroscience et santé mentale de Québec" (CINQ)
Pays : International
Organisme : Chercheur Boursier Award
Pays : International
Organisme : Réseau Québécois de Recherche en Vieillissement (RQRV)
Pays : International
Organisme : Fonds de Recherche du Québec Société et Culture (FRQ-SC)
Pays : International
Organisme : Fondation du CHU de Québec
Pays : International
Organisme : Canadian Institutes of Health Research (CIHR)
Pays : International
Organisme : Fonds de Recherche du Québec Santé (FRQ-S)
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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