Lithium and glutamine synthetase: Protective effects following stress.
Animals
CA1 Region, Hippocampal
/ drug effects
Cell Proliferation
/ drug effects
Disease Models, Animal
Glutamate-Ammonia Ligase
/ drug effects
Lithium Compounds
/ pharmacology
Male
Mice
Psychotropic Drugs
/ pharmacology
Sex Factors
Sodium Chloride
/ pharmacology
Stress, Psychological
/ prevention & control
beta Catenin
/ drug effects
Reporter mouse model
Sex differences
Wnt/β-catenin signaling
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
26
02
2019
revised:
29
08
2019
accepted:
29
08
2019
pubmed:
10
9
2019
medline:
21
4
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
Even though lithium is widely used as treatment for mood disorders, the exact mechanisms of lithium in the brain remain unknown. A potential mechanism affects the downstream target of the Wnt/β-catenin signaling pathway, specifically glutamine synthetase (GS). Here, we investigate the effect of lithium on GS-promoter activity in the brain. Over seven days, B6C3H-Glultm
Identifiants
pubmed: 31499341
pii: S0165-1781(19)30504-9
doi: 10.1016/j.psychres.2019.112544
pii:
doi:
Substances chimiques
Lithium Compounds
0
Psychotropic Drugs
0
beta Catenin
0
Sodium Chloride
451W47IQ8X
Glutamate-Ammonia Ligase
EC 6.3.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112544Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.