Multiplatform Urinary Metabolomics Profiling to Discriminate Cachectic from Non-Cachectic Colorectal Cancer Patients: Pilot Results from the ColoCare Study.

cancer cachexia colorectal cancer metabolomics serial samples urinary profiles

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
06 Sep 2019
Historique:
received: 16 07 2019
revised: 26 08 2019
accepted: 04 09 2019
entrez: 11 9 2019
pubmed: 11 9 2019
medline: 11 9 2019
Statut: epublish

Résumé

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Identifiants

DOI: 10.3390/metabo9090178 PMID: 31500101 PMC: PMC6780796
pubmed: 31500101
pii: metabo9090178
doi: 10.3390/metabo9090178
pmc: PMC6780796
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : K07 CA222060
Pays : United States
Organisme : Lackas Foundation
ID : NA
Organisme : Stiftung Lebensblicke
ID : NA
Organisme : NCI NIH HHS
ID : R01 CA207371
Pays : United States
Organisme : ERA-NET on Translational Cancer Research (TRANSCAN)
ID : 01KT1503
Organisme : NCI NIH HHS
ID : U01 CA206110
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA189184
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States

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Auteurs

Jennifer Ose (J)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. jennifer.ose@hci.utah.edu.
Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. jennifer.ose@hci.utah.edu.
ORCID: 0000-0002-2030-9676

Biljana Gigic (B)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. biljana.gigic@med.uni-heidelberg.de.

Tengda Lin (T)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. Tengda.lin@hci.utah.edu.

David B Liesenfeld (DB)

Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 69117 Heidelberg, Germany. davidliesenfeld@gmx.de.

Jürgen Böhm (J)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. boehm.juergen@outlook.com.

Johanna Nattenmüller (J)

Diagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, Germany. johannawelzel@gmail.com.

Dominique Scherer (D)

Institute of Medical Biometry and Informatics, University of Heidelberg, 69117 Heidelberg, Germany. Dominique.Scherer@uni-heidelberg.de.
ORCID: 0000-0003-4430-296X

Lin Zielske (L)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. l.zielske@dkfz-heidelberg.de.

Petra Schrotz-King (P)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. petra.schrotz-king@nct-heidelberg.de.

Nina Habermann (N)

European Molecular Biology Laboratory (EMBL), Genome Biology, 69117 Heidelberg, Germany. nina.habermann@embl.de.

Heather M Ochs-Balcom (HM)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. hmochs2@buffalo.edu.
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14260, USA. hmochs2@buffalo.edu.

Anita R Peoples (AR)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. anita.peoples@hci.utah.edu.
Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. anita.peoples@hci.utah.edu.

Sheetal Hardikar (S)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. sheetal.hardikar@hci.utah.edu.
Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. sheetal.hardikar@hci.utah.edu.

Christopher I Li (CI)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. cili@fredhutch.org.

David Shibata (D)

Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA. dshibata@uthsc.edu.

Jane Figueiredo (J)

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Jane.Figueiredo@cshs.org.

Adetunji T Toriola (AT)

Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St. Louis, MO 63110, USA. toriolaa@wudosis.wustl.edu.

Erin M Siegel (EM)

Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Erin.Siegel@moffitt.org.

Stephanie Schmit (S)

Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Stephanie.Schmit@moffitt.org.

Martin Schneider (M)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. martin.schneider@med.uni-heidelberg.de.

Alexis Ulrich (A)

Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. aulrich@lukasneuss.de.

Hans-Ulrich Kauczor (HU)

Diagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, Germany. Hans-Ulrich.Kauczor@med.uni-heidelberg.de.

Cornelia M Ulrich (CM)

Huntsman Cancer Institute, Salt Lake City, UT 84112, USA. neli.ulrich@hci.utah.edu.
Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA. neli.ulrich@hci.utah.edu.

Classifications MeSH