The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of

Atherosclerosis / genetics Cells, Cultured E2F3 Transcription Factor / genetics Gene Expression Regulation / genetics Genetic Predisposition to Disease / genetics Histone Deacetylases / genetics Humans Polymorphism, Single Nucleotide Repressor Proteins / genetics Retinoblastoma Binding Proteins / genetics Ubiquitin-Protein Ligases / genetics
atherosclerosis chromosome coronary artery disease proteome transcription

Journal

Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266

Informations de publication

Date de publication:
10 2019
Historique:
pubmed: 11 9 2019
medline: 21 3 2020
entrez: 11 9 2019
Statut: ppublish

Résumé

Background and Purpose- Genome-wide association studies have identified the

Identifiants

DOI: 10.1161/STROKEAHA.119.026112 PMID: 31500558
pubmed: 31500558
doi: 10.1161/STROKEAHA.119.026112
doi:

Substances chimiques

E2F3 Transcription Factor 0
E2F3 protein, human 0
RB1 protein, human 0
Repressor Proteins 0
Retinoblastoma Binding Proteins 0
Ubiquitin-Protein Ligases EC 2.3.2.27
HDAC9 protein, human EC 3.5.1.98
Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2651-2660

Subventions

Organisme : British Heart Foundation
ID : SP/16/4/32697
Pays : United Kingdom

Auteurs

Matthias Prestel (M)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Caroline Prell-Schicker (C)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Tom Webb (T)

Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom (T.W., M.G.N., N.J.S.).

Rainer Malik (R)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Barbara Lindner (B)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Natalie Ziesch (N)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Monika Rex-Haffner (M)

Department of Translational Research in Psychiatry, Max-Planck-Institute for Psychiatry, Germany (M.R.H., S.R.).

Simone Röh (S)

Department of Translational Research in Psychiatry, Max-Planck-Institute for Psychiatry, Germany (M.R.H., S.R.).

Thanatip Viturawong (T)

Department of Proteomics and Signal Transduction, Max-Planck-Institute for Biochemistry, Martinsried, Germany (T.V., M.L., M. Mann).

Manuel Lehm (M)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).
Department of Proteomics and Signal Transduction, Max-Planck-Institute for Biochemistry, Martinsried, Germany (T.V., M.L., M. Mann).
Abteilung für Diagnostische und Interventionelle Neuroradiologie, Klinikum rechts der Isar, Munich, Germany (M.L.).

Michal Mokry (M)

Department of Pediatrics (M. Mokry), University Medical Center Utrecht, the Netherlands.

Hester den Ruijter (H)

Laboratory of Experimental Cardiology (H.d.R., S.H.), University Medical Center Utrecht, the Netherlands.

Saskia Haitjema (S)

Laboratory of Experimental Cardiology (H.d.R., S.H.), University Medical Center Utrecht, the Netherlands.

Yaw Asare (Y)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Flavia Söllner (F)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).
Department of Physiological Chemistry, Biomedical Center Munich, Ludwig-Maximilians-Universität München, Germany (F.S.).

Maryam Ghaderi Najafabadi (MG)

Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom (T.W., M.G.N., N.J.S.).

Rédouane Aherrahrou (R)

Center for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville, (R.A., M.C.).

Mete Civelek (M)

Center for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville, (R.A., M.C.).

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, University of Leicester and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom (T.W., M.G.N., N.J.S.).

Matthias Mann (M)

Department of Proteomics and Signal Transduction, Max-Planck-Institute for Biochemistry, Martinsried, Germany (T.V., M.L., M. Mann).

Christof Haffner (C)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).

Martin Dichgans (M)

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Germany (M.P., C.P.S., R.M., B.L., N.Z., M.L., Y.A., F.S., C.H., M.D.).
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.).

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Cellules › Cellules cultivées › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription E2F › Facteur de transcription E2F3 › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines de liaison à la protéine du rétinoblastome › The Atherosclerosis Risk Variant rs2107595...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › The Atherosclerosis Risk Variant rs2107595...