Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion.
Adult
Anti-Bacterial Agents
/ administration & dosage
Humans
Infusions, Intravenous
Male
Microbial Sensitivity Tests
Middle Aged
Pneumonia, Bacterial
/ drug therapy
Pneumonia, Pneumococcal
/ drug therapy
Pneumonia, Staphylococcal
/ drug therapy
Respiratory Mucosa
/ chemistry
Staphylococcus aureus
/ drug effects
Streptococcus pneumoniae
/ drug effects
Teicoplanin
/ administration & dosage
Young Adult
dalbavancin
lung epithelial lining fluid
pharmacodynamics
pharmacokinetics
pneumonia
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
05
2019
accepted:
24
08
2019
pubmed:
11
9
2019
medline:
20
8
2020
entrez:
11
9
2019
Statut:
epublish
Résumé
Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC
Identifiants
pubmed: 31501147
pii: AAC.01024-19
doi: 10.1128/AAC.01024-19
pmc: PMC6811436
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Teicoplanin
61036-62-2
dalbavancin
808UI9MS5K
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Rappo et al.
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